Membrane attack complex group of complement components C5 C9 that bind to lipid

Membrane attack complex group of complement

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Membrane attack complex: group of complement components (C5-C9) that bind to lipid bilayer of cell membranes forming cylindrical channels (pores) of target cells allow influx of H2O cell lysis & death Kinin Turned into bradykinin pain, chemotaxis, & ↑ vascular permeability/vasodilation Coagulation Cascade Activates kinin system via Factor XII (Hageman factor) Forms fibrin mesh stops bleeding & traps microorganisms b.Analyze the steps of the arachidonic acid pathway. 6.Analyze disorders which affect immune function. c.Identify the etiology, pathophysiology and clinical manifestations of an allergic immune response. Etiology:
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o Immediate hypersensitivity response to an environmental allergen o Most reactions attributed to food, meds, pollen, etc. Patho: o Initial exposure to allergen IgE binds w/ allergen antigen-IgE complex primes stage for reaction to occur later o Re-exposure to allergen allergen (antigen) binds w/ previously formed antigen-IgE complex complex detected by mast cells degranulation of complex release of histamine triggers inflammatory cascade Clinical manifestations: o Dependent on route the allergen entered body Urticaria Rhinitis Conjunctivitis Asthma Angioedema (idiopathic or r/t meds) Anaphylaxis (most severe): Itching Hives Angioedema N/V/D/abd cramps Wheezing Dyspnea Laryngeal edema Hypotension Shock Death Atopic D/O: Hay fever Asthma Eczema Urticaria d. Differentiate between the processes of autoimmunity and alloimmunity. Autoimmunity: o Disturbance in the immunologic tolerance of self-antigens o Autoimmune diseases occur when the immune system reacts against self-antigens to such a degree that the person’s own tissues are damaged by autoantibodies or autoreactive T-cells Alloimmunity: o Occurs when person mounts an immune response to another member of the same species’ antigens/tissues E.g. ABO incompatibility, Rh incompatibility, blood transfusion immunologic reaction, organ transplant rejection
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