PHRM 514 - Asthma - Fall 2012 (1)

Have you used any medications that help you breathe

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Have you used any medications that help you breathe better? How often? ¡ Are your symptoms relieved when the medications are used? n In the past four weeks, have you had coughing, wheezing, or shortness of breath… ¡ At night that has awakened you? ¡ Upon awakening? ¡ After running, moderate exercise, or other physical activity? Kell HW, Sorkness CA. Asthma. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 7th ed. New York: McGraw Hill Medical; 2008. P. 463-72.
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What changes would we expect to see with spirometry?
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List 3 airway cells involved in airway inflammation.
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May shed which may result in heightened airway responsiveness, altered permeability of the airway mucosa, and loss of enzymes responsible for breaking down proinflammatory mediators. 1. Eosinophils 2. Epithelial cells 3. Mast cells 4. Lymphocytes 5. Alveolar macrophages
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Once activated by an allergen via an IgE receptor, these cells initiate the release of histamine, chemotactic factors, leukotrienes, prostaglandins, and platelet activating factor 1. Eosinophils 2. Epithelial cells 3. Mast cells 4. Lymphocytes 5. Alveolar macrophages
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Increased in numbers in the airways of those with asthma and release inflammatory mediators such as leukotrienes and granule proteins to injure airway tissue 1. Eosinophils 2. Neutrophils 3. Fibroblasts 4. Alveolar macrophages 5. Mast cells
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High numbers found in the airways of patients who died from sudden onset fatal asthma and in those with severe disease, but role in asthma unclear. 1. Myofibroblasts 2. Inflammatory mediators 3. Eosinophils 4. Alveolar macrophages 5. Neutrophils
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Airway hyperresponsiveness is… 1. Limitation of airflow 2. Blockage of the airways 3. Exaggerated bronchoconstrictor response 4. Reduced bronchoconstrictor response 5. Excessive airflow
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Airway obstruction may be caused by… 1. Bronchoconstriction 2. Airway edema 3. Airway hyperresponsiveness 4. Airway remodeling 5. All of the above
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Increased mucus secretion and excess epithelial and inflammatory cells may result in…
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Asthma is principally a disease diagnosed in which of the following populations? 1. Adults 2. Geriatrics 3. Pediatrics
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Questions n Email: [email protected] n Office hours: ¡ By appointment
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Have you used any medications that help you breathe better...

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