Lecture_3-Neurotransmission_Review

Synaptic transmission axodendritic or axosomatic

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Synaptic Transmission Axodendritic or axosomatic Axoaxonal Autoreceptor Self-regulation Dendroaxonic (retrograde signaling) “Real life”
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Types of synapses Active zones: contain the docking machinery for vesicular release; high in calcium channels; presynaptic side Post-synaptic density: complex of over 100 different proteins (incl. receptors, intracellular signaling mechanisms and ion channels)
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Generation of action potential in Axon Hillock Axon Hillock (Initial Segment) -high in voltage-gated Na + Channels
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Ionic imbalance at rest 1. Random motion (concentration gradients) 2. Electrostatic pressure 3. Ion permeability 4. Active transport
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Spatial summation: The effects of inputs coming into 2 different spaces on a neuron will add together
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Temporal summation: The effects of inputs coming into the same place will add together across time
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e.g. Na+ channels 1. Channel Closed (at rest) 2. Channel Opens (ions rush in) 3. Channel Closes (ions diffuses) Bottom (Inside) View Side View
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The action potential-massive depolarization of the membrane potential
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Ion channels in action potentials
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Ion Channels in action potentials
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Local anesthetics block Na+ channels (e.g., lidocaine, cocaine, procaine) no action potentials no conductance of pain information Note the interaction between hydrogens on lidocaine and the receptor site on the Na+ channel hydrogen bonding/van der Waals forces TTX: puffer fish venom
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Node of Ranvier Myelination : speeds up electrical signal Saltatory conduction : “jumping” of electrical signal from node to node http://www.brainviews.com/abFiles/AniSalt.htm
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Synaptic Transmission Axodendritic or axosomatic Axoaxonal...

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