15-introduction-fang2018.txt

4344 these compounds can be prepared through the ag

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cycloheptadiene.43,44 These compounds can be prepared through the Ag-mediated ring opening of a nitrosourea derivative of bicyclo[4.1.0]heptane. In unspecified yields, the AgClO4?3-methoxy-trans-cycloheptene complex was combined with a number of dienes to give the products of metal decomplexation and [4+2] cycloaddition.43,44
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Because C-Si bonds are long, the inclusion of silicon into the cyclic backbone can alleviate olefinic strain and impart stability to trans-cycloalkenes.45 C52 In 1997, (E)-1,1,3,3,6,6-hexamethyl- 1-sila-4-cycloheptene was synthesized, resolved, and characterized crystallographically.46,47 Here, the exhaustive allylic substitution imparts a high degree of stability to the trans-alkene. Recent studies by Woerpel48-51 and Tomooka52 have provided demonstrations of the utility of backbone heteroatom-containing trans-cycloalkene derivatives in synthesis. Woerpel has elegantly developed a general method for the preparation of trans-oxasilacycloheptenes seven �� membered rings that contain trans-alkenes and siloxy bonds in the backbone.48-51 There has been little investigation into the reaction chemistry of trans-cycloheptene derivatives. In 1980, Jendralla showed that silver complexes of 3-methoxy-trans-cycloheptene are isolable, and can reversibly dissociate and in unspecified yields undergo cycloaddition reactions.43,44 Woerpel has described selective addition reactions and difunctionalization reactions of trans-oxasilacycloheptenes, and recently has reported the
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