Sometimes acute influenza like fever with non

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Sometimes: acute influenza-like Fever with non-productive cough Calcified lesions in lungs Occasionally dev acute progressive form with: Widespread ifx of RES Dissemination in Joints- athralgia/arthritis Skin- erythema nodosum, erythema multiforme Heart- pericarditis Liver failure Renal failure Resp failure Meningitis, cerebritis, focal brain lesion usually in old aged, infancy & Ixcmprmsd Chronic: (like tuberculosis!) Adults large cavities in lungs from primary lesions or reactivation of old lesions In nature: saprophyte X reservoir known Enter host via lungs (inhalation) Geo dtrbtn: South Central America Ulcerative, granulomatous ifx of lungs, oral & nasal mucosa & adjacent skin Lymphatic system, spleen, intestine, adrenal glans and liver Dx Microscopy: Sputum, pus –Giemsa stain/ Wright Blood smear mat be +ve esp mild cases Small oval yeasts cells packed within mΦs/monocytes Culture: Sabaroud’s agar 25-30 C 37 C in cystein rich medium form yeast Serology: Precipitation test Complement fixation test Latex particle agglutination test ELISA Microscopy: Culture Skin test Serology Rx Mild: Ketaconazole Itraconazole Severe: Amphotericin B Used in HIV/AIDS patients
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