Excitation contraction coupling Less Ca 2 from sarcoplasmic reticulum with age

Excitation contraction coupling less ca 2 from

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Excitation-contraction coupling: Less Ca 2+ from sarcoplasmic reticulum with age. Reduces contractile force. 3. Changes in Biochemical Properties The 3 pathways of energy production in cell: 1. Phosphocreatine ( PCr ) 2. Glycolysis ( PFK , HK ) 3. Mitochondrial respiration ( COX , CS= markers ) Activity of nearly all the markers decreases with age except for some markers of glycolysis (e.g. PFK). Phosphofructokinase ( PFK ) – glycolytic pathway, rate limiting step Citrate synthase ( CS ) – Krebs cycle Cytochrome c oxidase ( COX ) – ETC Hexokinase ( HK ) – transport of glucose into muscle cell, rate limiting step Lactate dehydrogenase ( LDH ) – converts lactate to pyruvic acid
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²0–0²– 11 Diseases Affecting the MSK System Parkinson’s disease Muscular dystrophy Huntington’s disease Osteoarthritis Rheumatoid arthritis Ankylosing spondylitis Fibromyalgia Osteoporosis 4. Aging MSK System and Exercise Loss of muscle fibers cannot be completely reversed. But Can attenuate the rate of loss of fibers and muscle size with resistance and endurance exercise. With exercise, muscle can still hypertrophy in older age. 7
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²0–0²– 11 McLeod, M., Breen, L., Hamilton, D.L. et al. Biogerontology (2016) 17: 497. s10522-015-9631-7 Geoffrey A.Power; Brian H.Dalton; Charles L.Rice. Human neuromuscular structure and function in old age: A brief review. Journal of Sport and Health Science. Volume 2, Issue 4, December 2013, Pages 215-226 Fig. 2. Motor unit number estimates (MUNE) in masters athletes and old men. MUNE did not differ between masters runners (MR, ~ 65 years) and young men (Y, ~ 25 years), but were higher in MR than old men (O, ~ 65 years), and less in O compared with Y.
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  • Fall '19
  • jay johnson
  • loss of muscle mass, sarcopenia

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