Describe the key pathophysiologic concepts. To answer this question completely, you must answer all of the sub-questions below using complete sentences. Each sub-question may be answered in 1-6 sentences.
a. Describe the genetic alteration which results in sickle cell anemia. 1. It is caused by hemoglobin S. This genetic mutation occurs when valine amino acid replaces glutamate amino acid in the B-globin hemoglobin chain. b. What is the pathological process which is responsible for causing this patient’s joint pain? 1. The hemoglobin S molecules turn the biconcave red blood cells into a sickle shaped red blood cell. This happens when there is a lack of oxygen, and these sickle shaped cells clog blood vessels. This causes occlusions in various areas of the body including the joints, causing pain at the site. c. Why did this patient have a stroke 16 years ago? 1. This patient most ;likely had a stroke due to a vaso-occlusiove crisis occurring in vessels that supply oxygen to the brain. This resulted in a stroke d. Why did this patient have a splenic infarct? 1. e. Why does this patient have icteric sclera and an elevated bilirubin? f. What is Acute Chest Syndrome? Does she or does she not have this? Cxr is clear. 5. For what actual or potential complications related to the diagnosis in question 1 does she need to be monitored? You may simply list your answer(s) below using a bullet point format. This does not have to bein a complete sentence.
- Fall '15