Ovid: Wintrobe's Atlas of Clinical Hematology Figure 1.31 Top panel: Gums in lead poisoning. Lead lines are shown in gums of this patient suffering from lead poisoning. Bottom panel: Peripheral blood film demonstrating coarse basophilic stippling. Normocytic or microcytic anemia may be present. P.21 (PDF)/Wintrobe's%...matology,%201st%20Edition/1%20-%20Anemia.htm (34 of 81) [2007/11/13 11:09:19]
Ovid: Wintrobe's Atlas of Clinical Hematology (PDF)/Wintrobe's%...matology,%201st%20Edition/1%20-%20Anemia.htm (35 of 81) [2007/11/13 11:09:19]
Ovid: Wintrobe's Atlas of Clinical Hematology Diagram 1.3 Approach to normocytic anemia P.22 P.23 Figure 1.32 Top panel: Bone marrow aspirate demonstrating a hypocellular fragment from a patient with aplastic anemia. Although bone marrow cellularity can be estimated from fragments on the aspirate, the bone marrow biopsy is a better sample to estimate cellularity. Bottom panel: Aplastic bone marrow biopsy showing <10% cellularity. (PDF)/Wintrobe's%...matology,%201st%20Edition/1%20-%20Anemia.htm (36 of 81) [2007/11/13 11:09:19]
Ovid: Wintrobe's Atlas of Clinical Hematology Figure 1.33 Parvovirus B19-induced pure red cell aplasia. Left panel: Bone marrow aspirate smear shows a giant erythroblast with intranuclear viral inclusion. This inclusion can resemble a large nucleolus, and the cytoplasm may be dark blue and contain vacuoles. Right panel: Bone marrow biopsy with early erythroid precursors showing “ glassy ” intranuclear inclusions (so-called lantern cells; arrows ). P.24 Figure 1.34 Pure red cell aplasia. Bone marrow aspirate smear showing absence of erythroid precursors in PRCA. Table 1.6 Echinocytes ● Artifact ● Uremia and chronic renal disease ● Hypophosphatemia ● Disseminated malignancy ● Liver disease ● Vitamin E deficiency ● Pyruvate kinase deficiency ● Phosphoglycerate kinase deficiency ● Early posttransfusion of RBC ● Hyperlipidemia ● Myeloproliferative disorders Table 1.7 Teardrop cells (PDF)/Wintrobe's%...matology,%201st%20Edition/1%20-%20Anemia.htm (37 of 81) [2007/11/13 11:09:19]
Ovid: Wintrobe's Atlas of Clinical Hematology ● Myelofibrosis ● Bone marrow infiltration ● Megaloblastic anemia ● Hemolytic anemia ● Thalassemia major Figure 1.35 Echinocytes. Peripheral blood film demonstrating echinocytes, also called burr cells . The cells have central pallor and a diffuse, even distribution of short, bumpy projections with rounded edges around the surface of the red blood cell. Echinocytes resemble a bottle cap when viewed from above. This blood film could represent an example of anemia of chronic disease. The latter usually demonstrates a normocytic, normochromic anemia. Microcytosis and hypochromasia can develop as the severity of the underlying disease increases. The red blood cells may appear normal, demonstrate nonspecific changes, or display features secondary to the underlying cause (e.
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