Minimal change disease is characterized by selective

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MINIMAL CHANGE DISEASE IS CHARACTERIZED BY SELECTIVE PROTEINURIA (LOSS OF ALBUMIN) HYPERTENSION AND HEMATURIA IS RARE IN MINIMAL CHANGE DISEASE. EDEMA IS THE PRESENTING FEATURE (DUE TO LOSS OF ALBUMIN) PROGNOSIS IS EXCELLENT IN CASES OF MINIMAL CHANGE DISEASE. 125
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IT DOES NOT PROGRESS TO RENAL FAILURE EXCELLENT RESPONSE TO CORTICOSTEROID SERUM COMPLEMENT LEVEL REMAINS NORMAL. THE BASIC PATHOGENESIS OF MINIMAL CHANGE GLOMERULONEPHRITIS IS LOSS OF THE BASEMENT MEMBRANE POLYANION. (HEPARAN SULFATE PROTEOGLYCAN). 126
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A CHILD HAD HEMATURIA AND NEPHROTIC SYNDROME (MINIMAL CHANGE DISEASE) WAS DIAGNOSED. TRUE ABOUT IT IS- (AIIMS NOV 01) A) A TYPE OF FOCAL SEGMENTAL GN B) IGA DEPOSITION ON BASEMENT MEMBRANE C) FOOT PROCESS OF GLOMERULAR MEMBRANE NORMAL D) GLOMERULAR FUNCTION IS LOST DUE TO LOSS OF POLY CHARGE ON BOTH SITES OF GLOMERULAR FOOT PROCESS. ANS:D 127
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MINIMAL CHANGE DISEASE IS/ARE CAUSED BY - A) RIFAMPICIN B) IFN-ALPHA (PGI NOV 09) C) NSAIDS D) GOLD E) MERCURY 128
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MINIMAL CHANGE DISEASE IS/ARE CAUSED BY - A) RIFAMPICIN B) IFN-ALPHA (PGI NOV 09) C) NSAIDS D) GOLD E) MERCURY ANS. IS ‘A’ I.E., RIFAMPICIN; ‘B’ I.E., IFN-A; ‘C’ I.E., NSAIDS; ‘D’ I.E., GOLD & ‘E’ I.E., MERCURY 130
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MINIMAL CHANGE GLOMERULOPATHY MAY BE SEEN IN ASSOCIATION WITH ALL OF THE FOLLOWING EXCEPT - A) HEPATITIS B (AIMS NOV 05) B) HIV C) DRUG-INDUCED INTERSTITIAL NEPHRITIS D) HODGKIN'S DISEASE ANS. IS ‘A’ I.E., HEPATITIS B [REF: HARRISON 18,H] 131
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MEMBRANOUS GLOMERULONEPHRITIS MEMBRANOUS GLOMERULONEPHRITIS IS ASSOCIATED WITH- A) RENAL VENOUS THROMBOSIS (PGI JUNE 02) B) HODGKIN’S DISEASE C) SUBEPITHELIAL IMMUNE DEPOSITS D) HEMATURIA E) ACUTE NEPHRITIS 132
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MEMBRANOUS GLOMERULONEPHRITIS CLINICAL FEATURES OF MEMBRANOUS GLOMERULONEPHRITIS :- MOST COMMON PRESENTATION OF MEMBRANOUS GLOMERULOPATHY IS NEPHROTIC SYNDROME INFACT, IT IS THE MOST COMMON CAUSE OF NEPHROTIC SYNDROME IN ADULTS. THROMBOSIS IS COMMON IN PATIENTS WITH NEPHROTIC SYNDROME. RENAL VEIN THROMBOSIS OCCURS IN UPTO 40% OF PATIENTS WITH NEPHROTIC SYNDROME AND IS PARTICULARLY COMMON WHEN NEPHROTIC SYNDROME IS CAUSED BY MEMBRANOUS OR MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS. 133
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ABOUT ONE THIRD OF ADULT MEMBRANOUS NEPHROPATHY OCCURS IN ASSOCIATION WITH SYSTEMIC DISEASES SUCH AS SLE, INFECTIONS SUCH AS HEPATITIS B, MALIGNANCY AND DRUG THERAPY WITH GOLD AND PENICILLAMINE. NOTE THAT BOTH MEMBRANOUS AND MINIMAL CHANGE G N. CAUSE NEPHROTIC SYNDROME BUT THERE ARE SOME IMPORTANT DIFFERENCES. PROTEINURIA IS NOT SELECTIVE IN MEMBRANOUS G.N. DOES NOT RESPOND WELL TO CORTICOSTEROIDS. MINIMAL CHANGE DISEASE IS ASSOCIATED WITH LYMPHOPROLIFERATIVE MALIGNANCY BUT NOT MEMBRANOUS NEPHROPATHIES. 134
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MEMBRANOUS GLOMERULONEPHRITIS MEMBRANOUS GLOMERULONEPHRITIS IS ASSOCIATED WITH- A) RENAL VENOUS THROMBOSIS (PGI JUNE 02) B) HODGKIN’S DISEASE C) SUBEPITHELIAL IMMUNE DEPOSITS D) HEMATURIA E) ACUTE NEPHRITIS 136
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INFECTION:- .
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