Toxicologia_Fundamental_Repetto_4ª_Edicion_booksmedicos.org.pdf

# V 94 toxicología fundamental momento de la

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% en orina de dosis i.v. 94 TOXICOLOGÍA FUNDAMENTAL

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En un modelo bicompartimental, en el estado de equilibrio, el volumen de distribución total es: V T = V c + V p , luego: V = V c + V c K K 1 2 2 1 = V c (1 + K K 1 2 2 1 ), de donde V T = V c expresión que permite calcular el volumen de dis- tribución total a partir de las curvas de nivel. De la fase exponencial (último tramo) de estas curvas puede calcularse de forma simplificada V d extrapo- lando dicho tramo hasta el eje, para obtener un valor de concentración B o , y Vd = D B os o is Un hombre de 70 kg de peso corporal tiene aproximadamente 5,5 l de sangre, 3 l de plasma sanguíneo, 12 l de plasma extracelular y 42 l de agua corporal.

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