exam_2013-spring-3-answers

15 marks pain relievers antipyretic for fever effect

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( 1.5 marks ). Pain relievers Antipyretic (for fever) effect Anti-inflammatory effect
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27. List four (of the six) side effects of antipsychotics ( 2 marks ). 1. Parkinsonism: akinesia, rigidity, tremor. 2. Neuroleptic malignant syndrome 3. Akathisia - tremendous urge to move around 4. Tardive dyskinesia: involuntary muscle movement in mouth, neck, chest. 5. Pseudopregnancy: DA inhibits prolactin release; antipsychotics blocks release of FSH & LH - woman doesn’t ovulate 6. Seizures at high doses BONUS. In class I gave you four reasons why lipid-based theories of anesthetic action based on the Meyer-Overton correlation were abandoned in the 1980s and 1990s in favour of protein-based theories. Give me as many of the four as you can remember and each is worth a half mark bonus! 1. Discovery of non-immobilizers that would be predicted to be good anesthetics based on their oil:gas partition coefficients 2. Cutoffs in alcohols or alkanes - no further increases in potency with chain length 3. Small changes in bulk fluidity produced by anesthetics are mimicked by 1C change in temperature 4. Stereoisomers of some anesthetics (like isoflurane and etomidate) vary in potency There’s a fifth that I didn’t mention in class. The compound fluorothyl (Indoklon) is a halogenated ether that looks quite like an anesthetic if one looks at its chemical structure, and according to Meyer-Overton it should be a pretty potent anesthetic. However it acts as a convulsant instead and used to be used in shock therapy - basically a chemically- induced equivalent to electroconvulsive shock therapy.
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