are from the ingestion or administration of substances or drugs, gastrointestinal disorders, neurologic processes and metabolic disorders (Arcangelo et. al., 2017). Initiating treatment begins with evaluation and correction of possible causes. The goal of therapy is to eliminate the symptoms and the associated complications. In the case of HL, little information is given about onset, duration or severity. Your diagnosis based on the symptoms, history, and medications is Non-alcoholic steatohepatitis. Nonalcoholic steatohepatitis has become one of the most common liver-related health problems (Gitto et. al., 2015). It is a form of Non-Alcholic Fatty Liver Disease (NAFLD) in which you have hepatitis -inflammation of the liver-and liver cell damage, in addition to fat in your liver (What is NAFLD?, 2016). The disease could lead to cirrhosis or liver cancer. Affected individuals may be asymptomatic. NASH is associated with unhealthy diet and weight gain, but it can also be present in nonobese individuals. First-line approach to care involves lifestyle modifications; however, the use of medications has been proposed. The first-line pharmacological choices are Vitamin E and pioglitazone, both showing a positive effect on transaminase, fat accumulation, and inflammation (Gitto et. al., 2015). While researching for this weeks discussion, my findings were similar to yours. Liver disease can affect drug clearance, biotransformation, and pharmacokinetics. Some alterations increase levels of bioavailable drug, causing normal drug doses to have toxic effects (Herrine & Kimmel, 2018). If HL does have NASH, his liver function may affect the availability of the medications he is currently taking resulting in his symptoms. Liver function tests could determine if HL has impaired liver function. If the cause of HL’s symptoms is due to drug
toxicity due to impaired liver function, medication adjustments should help with resolving symptoms. References What is NAFLD? (2016). National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved from - nash/definition-facts Herrine, Steven & Kimmel, Sidney. (2018). Effects of Liver Disease on Drug Metabolism. Merck Manual . Retrieved from - and-biliary-disorders/drugs-and-the-liver/effects-of-liver-disease-on-drug-metabolism S. Gitto, G. Vitale, E. Villa, & P. Andreone. (2015). Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future. Gastroenterology Research and Practice . Retrieved from
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- Summer '15
- Gastroenterology, Week 7 Discussion, Prednisone, Hepatology, Hepatitis C