Lecture_5

Complex biological response of vascular tissues to

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Complex biological response oF vascular tissues to harmFul stimuli, such as : - pathogens - damaged cells - irritants
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25 Infammatory Response • Increased blood supply • Accumulation oF white blood cells at site oF inFection/injury • Chemicals/proteins that promote infammation —histamines, cytokines, Free radicals, prostaglandins • Examples oF infammatory response: pimple, gastritis, laryngitis, mucus production
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26 Steps in Infammatory Response Platelets Histamine Phagocytic cell Bacteria Skin Wound 4 3 2 1 1. Damaged tissues release histamine which increases blood fow 2. Histamine causes capillaries to leak releasing phagocytic cells and clotting Factors 3. Phagocytic cells engulF bacteria, dead cells and debris 4. Platelets seal the wound
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27 Infammation NonspeciFc reaction to noxious stimuli 5 classic signs o± infammation: • Erythema (redness) • Edema (swelling) • Pain • Heat (±ever) • Altered ±unction
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28 Infammation Movie http://www.youtube.com/watch?v=suCKm97yvyk&Feature=related
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29 Schematic illustration of blood vascular and lymphatic system
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30 Blood — Lymph Capillary Exchange
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31 Lymphatics and Organs of the Immune System Fluid = lymph Vessels = lymphatics
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Complex biological response oF vascular tissues to harmFul...

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