Fig. 16-15• When glucose blood level increases, insulin is released to the blood. • Another mechanism of insulin action is activation of glycogen synthesis. •The hormone binding to the insulin receptor leads to activation of pyruvate dehydrogenase phosphatase. •The enzyme dephosphorylation promotes the synthesis of acetyl-CoA. Regulation of the CAC
Regulation of the CAC• Ca2+is the cellular second-messenger that stimulates muscle contraction. •Simultaneously, Ca2+inhibits pyruvate dehydrogenase kinase but activates pyruvate dehydrogenase phosphatase, isocitrate dehydrogenase, and α-ketoglutarate dehydrogenase.
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