Being physically inactive (P), being obese (O) and having hypertension (H) Consuming sugar sweetened beverages (S), having a genetic predisposition to T2D (G), and being obese (O) a. Depict this scenario using causal pies. b. Is there a necessary cause for the development of diabetes based on this scenario? If yes, what is it? Yes, it is being obese (O) c. Which, if any, of the four exposures (G, H, R, P) interact with each other, and why? H & P interact with each other, as they are in the same causal pie d. Two studies were conducted to evaluate to what extent genetic predisposition determines T2D. One study was carried out in a population in which the prevalence of obesity was very low, and the average BMI was 22 kg/m 2 (population 1). Another study, which followed a similar design and protocol, was carried out in a different population, where the prevalence of obesity was very high, and the average BMI was 27 kg/m 2 (population 2). Assume the proportions of individuals that consume sugar sweetened beverages are the same in these two populations. Based on this information, do you expect the strength of the association between genetic predisposition and T2D to be stronger in one of the populations than the other? If so, which one? Explain your answer. Yes, I expect the strength of the association between genetic predisposition (G) and occurrence of T2D to be stronger in population 2 than in population 1. Population 2 has a higher prevalence of one of the component causes in the causal pie involving genetic predisposition (being obese, O), while population 1 has a lower prevalence of this component cause. As a result, the strength of the association between genetic predisposition and T2D will be stronger in population 2 than in population 1.
e. What is the sufficient and component cause model not telling us? The sufficient and component cause model cannot tell us about: o temporal order/sequence of the component causes o timing of action (induction periods) of the component causes o dose of component causes o preventive vs. harmful components
- Fall '18