IM DRUGS ABSORB QUICKER THAN SUBCUT DRUGS CUZ OF GREATER SUPPLY OF BLOOD DEPOT

Im drugs absorb quicker than subcut drugs cuz of

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-IM DRUGS ABSORB QUICKER THAN SUBCUT DRUGS CUZ OF GREATER SUPPLY OF BLOOD
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-DEPOT DRUGS: LONG-ACTING IM DOSAGE FORMS DESIGNED FOR SLOW ABSORPTION (DAYS TO A FEW MTS) --->TOPICAL ROUTE: -SLOWER ONSET, LONGER DURATION -SEE BOX 2-2 ON PAGE 24 FOR DRUG ROUTES THAT ARE FIRST PASS & NON-FIRST PASS (GOES THROUGH THE LIVER TO BE METABOLIZED -RECTAL ADMINISTERED MEDS ARE BOTH FIRST-PASS & NON-FIRST PASS -TRANSDERMAL ROUTE IS GOOD FOR PPL WHO CAN'T DO THE ORAL ROUTE -INHALED ROUTE: CONSIDERED A TOPICAL DRUG. THE DRUG IS INHALED TO THE ALVEOLI -DISTRIBUTION: -DRUGS GO TO LARGE BLOOD SUPPLY AREAS FIRST (HEART, BRAIN, KIDNEY, LIVER) THEN IT GOES TO MUSCLE, SKIN, & FAT -ALBUMIN CARRIES PROTEIN-BOUND DRUG MOLECULES, WHATEVER IS LEFT OVER THAT DOES NOT ATTACH TO ALBUMIN IS “FREE & ACTIVE” -PPL W/LOW ALBUMIN LEVELS (BAD BURNS & MALNOURISHED MAY HAVE DRUG TOXICITY CUZ OF “UNBOUND, FREE ACTIVE: PROTEIN MOLECULES ON THE DRUG -DRUG-DRUG INTERACTION: TWO DRUGS GIVEN AT THE SAME TIME DECREASE OR INCREASE THE ACTION OF ONE ANOTHER -DRUG DISTRIBUTION IS POOR IN SITES THAT DON’T HAVE A LOT OF BLOOD OR HAVE A BARRIER E.G BONE & BLOOD BRAIN BARRIER -METABOLISM -ANOTHER WORD FOR METABOLISM IS BIOTRANSFORMATION -HEPATIC METABOLISM INVOLVES P-450 ENZYMES (MICROSOMAL ENZYMES) TO HELP METABOLIZE LIPID SOLUBLE
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(LIPOPHILIC/NONPOLAR) DRUGS -SUBSTRATES: DRUGS THAT TARGET SPECIFIC ENZYMES IN THE LIVER -SEE TABLE 2-5 ON PAGE 26 FOR A LIST OF P-450 ENZYMES & THEIR CORRESPONDING SUBSTRATES -EXCRETION -PRIMARY EXCRETION ORGAN IS THE KIDNEYS -THEN IT’S THE LIVER AND BOWEL -BILIARY EXCRETION: EXCRETION OF MEDS THROUGH THE INTESTINES -BILIARY EXCRETION ROUTE: DRUGS TAKEN UP BY LIVER, THEN RELEASE IN BILE, THEN OUT THROUGH POOP -ENTEROHEPATIC RECIRCULATION: FAT-SOLUBLE DRUGS IN THE BILE GET REABSORBED INTO THE BLOOD; RETURN TO THE LIVER & AGAIN SECRETED IN THE BILE HALF-LIFE -AMT OF TIME IT TAKE FOR ONE HALF (50% OF THE DRUG TO BE REMOVED FROM OUR BODIES) -MOST DRUGS ARE REMOVED FROM THE BODY AFTER 5 HALF-LIVES -STEADY STATE: AMOUNT OF DRUG REMOVED FROM THE BODY (EXCRETED) EQUALS THE AMT OF DRUG ABSORBED IN EACH DOSE -STEADY STATE MEANS THERAPEUTIC EFFECTS REACHED TO MAX ONSET, PEAK, & DURATION -DRUG EFFECTS: ONSET
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  • Spring '17
  • Nursing, Route of administration, drug therapy

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