Lecture3_Gene_Regulate 1.49.03 AM

Gradients in regulatory proteins the great idea of

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Gradients in regulatory proteins.
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The Great Idea of Jacob and The Great Idea of Jacob and Monod: Genes that Control Genes Monod: Genes that Control Genes Observations on phage life cycle and bacterial growth in presence of different sugars led to picture of gene regulation. Use of sugars other than glucose (such as lactose) seemed to be tightly controlled. (Muller-Hill)
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How Are Genes Regulated? How Are Genes Regulated? Genes can be regulated at many stages along the path from DNA to protein. Transcriptional control is one of the most important mechanisms and will be the focus of our discussion.
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RNA Polymerase: Bound or Not? RNA Polymerase: Bound or Not? (Cramer ‘02) (Ptashne and Gann) For us, the whole question of transcriptional regulation will come down to the question of whether or not RNAP is bound to the promoter or not! There are an array of molecules (transcription factors) that participate in recruiting RNAP to its promoter.
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Repressors: The Cartoon Repressors: The Cartoon Repressor molecules inhibit action of RNA polymerase.
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