B transduction c conjugation d transformation e

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B) transduction. C) conjugation. D) transformation. E) infecting a pathogenic Vibrio cholerae. 44) In response to the presence of endotoxin, phagocytes secrete tumor necrosis factor. This causes A) the disease to subside. B) a decrease in blood pressure. C) a fever. D) a gram-negative infection. E) an increase in red blood cells. 45) Patients developed inflammation a few hours following eye surgery. Instruments and solutions were sterile, and the Limulus assay was positive. The patients inflammation was due to A) bacterial infection. B) viral infection. C) endotoxin. D) exotoxin. E) The answer cannot be determined based on the information provided. Chapter 20 Antimicrobial Drugs 1) Penicillin was considered a miracle drug for all of the following reasons EXCEPT A) it was the first antibiotic. B) it does not affect eukaryotic cells. C) it inhibits gram-positive cell wall synthesis. D) it has selective toxicity. E) it kills bacteria. 2) A drug that inhibits mitosis, such as griseofulvin, would be more effective against A) gram-positive bacteria. B) gram-negative bacteria. C) fungi. D) wall-less bacteria. E) mycobacteria. 3) Most of the available antimicrobial agents are effective against A) viruses. B) bacteria. C) fungi. D) protozoa. E) All of the answers are correct.
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4) Antimicrobial peptides (AMPs) frequently work by A) inhibiting protein synthesis. B) disrupting the plasma membrane. C) complementary base pairing with DNA. D) inhibiting cell- wall synthesis. E) hydrolyzing peptidoglycan. 5) In what way are semisynthetic penicillins and natural penicillins alike? A) Both are broad spectrum. B) Both are resistant to penicillinase. C) Both are resistant to stomach acids. D) Both are bactericidal. E) Both are based on -lactam. 6) Which of the following antibiotics is NOT bactericidal? A) aminoglycosides B) cephalosporins C) polyenes D) rifampins E) penicillin 7) Which one of the following does NOT belong with the others? A) bacitracin B) cephalosporin C) monobactam D) penicillin E) streptomycin 8) Figure 20.1 The antibiotic tetracycline binds to the 30S subunit of the ribosome, as shown by the dark black bar on the right portion of the diagram in Figure 20.1. The effect is to A) prevent attachment of DNA. B) prevent peptide bond formation. C) prevent transcription. D) stop the ribosome from moving along the mRNA. E) interfere with the attachment of the tRNA to mRNA-ribosome complex. 9) Figure 20.2 The antibiotic chloramphenicol binds to the 50S subunit of the ribosome, as shown in Figure 20.2. The effect is to A) prevent mRNA-ribosome binding in eukaryotes. B) prevent peptide bond formation in prokaryotes. C) prevent polypeptide elongation in eukaryotes. D) prevent transcription in prokaryotes. E) prevent ribosome formation in bacteria. 10) Which of the following antimicrobial agents has the fewest side effects? A) streptomycin B) tetracycline C) penicillin D) erythromycin E) chloramphenicol 11) Which of the following drugs does NOT act by competitive inhibition? A) ethambutol B) isoniazid C) streptomycin D) sulfonamide E) trimethoprim 12) Which of the following methods of action would be bacteriostatic? A) competitive inhibition with folic acid synthesis
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  • Winter '18
  • Mok T. Chong, PharmD, PhD, MBA
  • Bacteria, tuberculosis C

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