prolonged activation of ABC pumps by ersatzdroges could force MDR cells to use limited resources on proliferation and invasion delaying the progression of the cancer. This approach offers a simple and novel application model of evolutionary-based mechanism that can help utilize the cost of resistance to delay the spread of drug-resistant cancer phenotypes. MDR is one of the major cause of chemotherapy failure (Yan et al. 79). As a result, the Yan et al. (79) came up with a small interfering (si)RNA and targeted drug co-delivery strategy rooted on specific aptamer-conjugated grapefruit-derived nanovectors (GNVs) to mitigate the MDR problem. As a result, the authors found that aptamer loaded on grapefruit-derived nanovectors (GNVs) enhanced doxorubicin (Dox) accumulation in multidrug resistant LoVo cells, a consequence that is solved by pretreatment using DNase. In particular, Yan et al. (79) found that the aptamer efficiently enhanced the internalization of nanovectors into the cell and improved targeted delivery of Dox to the tumors. Consequently, the researchers concluded that GNV-oriented systems were effective in mitigating MDR.
- Winter '14