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Building a fly bringing the whole course home through

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Building a Fly. Bringing the whole course home through the ex- ample of a fly and the development of an embryo. Transcription factors and the fly body plan. Diffusion in embryos. 3 Bibliography My logic in providing the following list of references is to give you a wide view of some of the important books (both pedagogically and as scholarly works) that have been written to describe this important field. In addition to the works listed here, you should count on a steady supply of readings from the current literature. Indeed, this course is going to be reading intensive since most of the audience will lack either the biological or physical background and will have to make up for such holes in part through extracurricular reading. One of my main hopes with this list is to avoid flying the flag of any particular discipline, whether it be biology, physics or chemistry. We should worry less about the names of disciplines and be more open to taking tools 4
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from whatever quarter they may be needed. NOTE: you will get much more out of the course if you make a point of doing the reading. B. Alberts, D. Bray, A. Johnson, J. Lewis, M. Raff, K. Roberts and P. Wal- ter, Essential Cell Biology , Garland Publishing, 2003. This book has become one of my prized possessions and is usually the first place I look each time I am trying to understand the current thinking on biological phenomena. D. Boal, Mechanics of the Cell , Cambridge University Press, 2001. This book will serve as one of the main texts for the quarter. Boal has assembled a very nice collection of insights into the ways in which mechanics can be applied to the living world. K. Sneppen and G. Zocchi, Physics in Molecular Biology , Cambridge Uni- versity Press, 2005. This book is one of a growing number of attempts on the part of physicists to make a case for the role of quantitative analysis and physical reasoning in attacking real biological problems. There are many interesting topics scattered throughout the book. S. Carroll, Endless Forms Most Beautiful , W. W. Norton and Company, 2005. This book is certainly one of the highlights of 2005 for me. I read it three times and think it is provocative and calls attention to some of the most interesting questions in biology. In particular, it addresses the connection between evolution and development. M. Kirschner and J. Gerhart, The Plausibility of Life , Yale University Press, 2005. This book is similar in spirit to that of Carroll and discusses the in- sights that modern molecular and developmental biology have provided into evolution. These same authors have written a second amazing book Cells, Embryos and Evolution . It is a very serious undertaking, but full of interest- ing ideas. A. Murray and T. Hunt, The Cell Cycle , Oxford University Press, 1993. This book is by two of the leaders in this field and though it is probably dated, it is full of interesting facts and ideas. Here too, I am keen on the idea of unleashing tools like those described in this class to think about real cell biology issues such as the cell cycle.
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