Women's Health Conditions (1)

Treatment with broad-spectrum antibiotics increase

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Unformatted text preview: Treatment with broad-spectrum antibiotics Increase risk of infection Systemic corticosteroid, antineoplastic, or immunosuppressant drugs Receptive oral sex Intrauterine device (IUD) Propagating a warm, moist environment Tight fitting, nonabsorbant clothing or pantyhose VVC Pathophysiology Determine severity Categorize: ◦ Uncomplicated Infrequent Mild-moderate symptoms ◦ Complicated (~5% of women) Severe symptoms Concurrent predisposing medication or illness Recurrent (≥4 documented infections in 1 year) Treatment of VVC Exclusions for Self-Treatment ◦ Complicated/Recurrent ◦ Pregnancy ◦ Girls < 12 years ◦ Concurrent symptoms of fever or pain in the abdomen, back or shoulder ◦ Medications that predispose to VVC ◦ Medical conditions that predispose to VVC Treatment of VVC Treatment goals: ◦ Relief of symptoms ◦ Reestablishment of normal vaginal flora Symptomatic improvement within 2-3 days and complete resolution within 1 week of treatment Nonpharmacologic treatment: ◦ Discontinue possible precipitating factors Treatment of VVC Agents: ◦ Butoconazole, Clotrimazole, Miconazole, Tioconazole ◦ Creams, Suppositories, Tablets ◦ 1-day, 3-days, 7-days treatment options MOA: ◦ Alters the membrane permeability of the fungi by inhibiting CYP450 enzymes in the fungi sterol ergosterol Imidazoles are equally effective Cure rates of 80-90% Pharmacologic Treatment of VVC: Vaginal antifungals (imidazoles): Topical preparations have minimal systemic absorption Side effects: ◦ Vulvovaginal burning, itching, and irritation ◦ Abdominal cramps ◦ Penile irritation ◦ Allergic reactions ◦ Headache Pharmacologic Treatment of VVC Nonprescription vaginal preparations for relief of vaginal itching and irritation: ◦ Symptom relief only ◦ Do NOT treat the infection ◦ Ingredients: Benzocaine and hydrocortisone ◦ Example products: Vagisil Yeast-Gard Pharmacologic Treatment of VVC Special Populations ◦ Pregnancy...
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Treatment with broad-spectrum antibiotics Increase risk of...

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