After a few more months went by his leukemia returned

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After a few more months went by, his leukemia returned and doctors decided to try a stem cell transplant , a risky procedure that kills nearly a third of patients. First report of AIDS cure
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12 Side effects of the conditioning process can include: * Nausea and vomiting * Diarrhea * Hair loss * Mouth sores or ulcers * Infections, such as pneumonia * Bleeding * Infertility or sterility * Premature menopause * Anemia * Fatigue * Cataracts * Organ failure, such as heart, liver or kidney failure * Secondary cancers During conditioning, patient undergoes chemotherapy and possibly radiation in order to: * Destroy cancer cells * Wipe out the bone marrow
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13 AIDS Cure http:// www.bloomberg.com/ apps/news? pid=20601124&refer=h ome&sid=ac9.rZCRCs8 Y
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18 Lecture 10: Clinical manifestation of AIDS • Definition of AIDS • CDC stages of HIV infections • Symptoms of stages • Tissue specific HIV-associated diseases 5/7/2013
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19 Definition of AIDS AIDS = very complex disease with multiple phases and symptoms Why is it important to have a definition? AIDS = stigma A person positive for HIV has HIV infection (not AIDS) To keep track of AIDS epidemic, physicians must report cases treated - must have clear definition to recognize AIDS Definition is important to understand disease
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20 In 1981 CDC defined AIDS as: A person suffering from Kaposi’s sarcoma or an infectious disease due to immune system impairment and there was no other reason for the impaired immune system In 1984 : HIV was identified Scientists developed blood test to detect Ab against HIV 1987 new definition of AIDS : Positive HIV test + 1 or more of 23 accompanying conditions (see Table 4.2, text, for complete list) Pg 95
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21 Notice that a HECK OF A LOT of diseases accompany HIV infection 23 conditions
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22 1993 Definition of AIDS • Positive HIV antibody test • Fewer than 200 CD4 + T lymphocytes per microliter of blood • 1 or more of about 26 different infections or cancers Number of AIDS cases increased significantly!!!
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