Mtdna mediated reversible control of metastasis

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mtDNA-mediated reversible control of metastasis, therefore, reveals a novel function of mtDNA and suggests that in such cases ROS scavengers may be therapeutically effective in suppressing metastasis. References and Notes 1. J. A. Allen, M. M. Coombs, Nature 287, 244 (1980). 2. J. M. Backer, I. B. Weinstein, Science 209, 297 (1980). 3. J. W. Shay, H. Werbin, Mutat. Res. 186, 149 (1987). 4. K. Polyak et al., Nat. Genet. 20, 291 (1998). 5. M. S. Fliss et al., Science 287, 2017 (2000). 6. J. S. Penta, F. M. Johnson, J. T. Wachsman, W. C. Copeland, Mutat. Res. 488, 119 (2001). 7. R. W. Taylor, D. M. Turnbull, Nat. Rev. Genet. 6, 389 (2005). 8. A. M. Czarnecka, P. Golik, E. Bartnik, J. Appl. Genet. 47, 67 (2006). 9. M. E. Gallardo et al., Hum. Mutat. 27, 575 (2006). 10. Y. Shidara et al., Cancer Res. 65, 1655 (2005). 11. J. A. Petros et al., Proc. Natl. Acad. Sci. U.S.A. 102, 719 (2005). 12. H. A. Coller et al., Nat. Genet. 28, 147 (2001). 13. R. W. Taylor et al., J. Clin. Invest. 112, 1351 (2003). 14. A. Salas et al., PLoS Med. 2, e296 (2005). 15. H. Kaneda et al., Proc. Natl. Acad. Sci. U.S.A. 92, 4542 (1995). 16. H. Shitara, J.-I. Hayashi, S. Takahama, H. Kaneda, H. Yonekawa, Genetics 148, 851 (1998). 17. B. E. Baysal et al., Science 287, 848 (2000). 18. S. Niemann, U. Muller, Nat. Genet. 26, 268 (2000). 19. E. Gottlieb, I. P. Tomlinson, Nat. Rev. Cancer 5, 857 (2005). 20. L. H. Augenlicht, B. Heerdt, Nat. Genet. 28, 104 (2001). 21. K. Takenaga, Y. Nakamura, S. Sakiyama, Oncogene 14, 331 (1997). 22. M. Takasu, Y. Tada, J. O. Wang, M. Tagawa, K. Takenaga, Clin. Exp. Metastasis 17, 409 (1999). 23. Materials and methods are available as supporting material on Science Online. 24. D. C. Wallace, Science 283, 1482 (1999). 25. S. De Flora et al., Int. J. Cancer 67, 842 (1996). 26. N. Koshikawa, C. Maejima, K. Miyazaki, A. Nakagawara, K. Takenaga, Oncogene 25, 917 (2006). 27. N. Koshikawa, A. Iyozumi, M. Gassmann, K. Takenaga, Oncogene 22, 6717 (2003). 28. This work was supported by Grants-in-Aid for Scientific Research (S) from the Japan Society for Promotion of Science (JSPS), by Grants-in-Aid for Creative Scientific Research from JSPS, and by Grants-in-Aid for Scientific Research on Priority Areas from The Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) to J.-I.H. This work was also supported by grants for a Research Fellowship from JSPS for Young Scientists to K.I. and by Grants-in-Aid for Third Term Comprehensive Control Research for Cancer from the Ministry of Health, Labour, and Welfare and for Scientific Research from MEXT to K.T. All animal experiments were performed in compliance with the institutional guidelines (Chiba Cancer Center and University of Tsukuba) for the care and use of laboratory animals. Supporting Online Material Materials and Methods Figs. S1 to S6 Tables S1 to S3 References 25 February 2008; accepted 25 March 2008 Published online 3 April 2008;
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10.1126/science.1156906 Include this information when citing this paper. In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish Scott T. Laughlin,1 * Jeremy M. Baskin,1 * Sharon L. Amacher,2 Carolyn R. Bertozzi1,2,3,4? Glycans are attractive targets for molecular imaging but have been inaccessible because of their incompatibility with genetically encoded reporters. We demonstrated the noninvasive imaging of glycans in live developing zebrafish, using a chemical reporter strategy. Zebrafish embryos were treated with an unnatural sugar to metabolically label their cell-surface glycans with azides.
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