Ma portion of gag and gag pol polyprotein binds to

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• MA Portion of Gag (and Gag-Pol) Polyprotein binds to Cytoplasmic Domains of TM Trimers MA almost certainly binds to the Cytoplasmic Domains of TM Trimers. • Gag Polyproteins oligomerize via CA Portion-CA Portion Interactions - Gag-Pol Polyproteins likewise bind via CA Portion-CA Portion Interactions with Gag Polyproteins • NC Portion of Gag Polyprotein binds to a 4 Stem-Loop Packaging Signal ( ψ ) [Greek Letter psi] at 5´ End of Full Length Dimers (Genomic) RNA • Cellular tRNA lys binds to RT and NC Portions of Gag-Pol • Immature Virus Particles Bud from the Cell • Budding Immature Virus Particle swipes some Host Cell Membrane for its Envelope • At the Time of Budding these Immature Virus Particles have Nested Layers (Outermost Layer) - Host Cell Membrane (now the Virus Envelope with SU/TM Trimers) - MA Portion of Gag Polyproteins - CA Portion of Gag Polyproteins - NC Portion of Gag Polyproteins, closely associated with… - RNA Dimer - PR-RT-IN of a small Number of Gag-Pol Polyproteins (Innermost Layer) HIV Maturation into Mature (Infectious) Virus Particles Autocatalytic Cleavage releases PR from Gag-Pol Polyprotein • PR becomes active as Virus is budding - Sequential Cleavages separate individual MA, CA, NC Proteins (as well as RT and IN) • CA undergoes Conformational Change when cleaved - CA form Tapered Cylindrical Core around RNA Dimers • RNA Dimers are bound to NC • MA remains (loosely) associated with Virus Envelope • SU/TM Trimers remain in Virus Envelope
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