Thyroid gland radioisotopic destruction of the

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thyroid gland, radioisotopic destruction of the thyroid gland by the use of 131 I, and surgical removal of the thyroid gland. After considering all the options, especially the possible effects of radiation on gamete development, Michael chose surgery. Following successful surgery, Michael was prescribed synthetic thyroid hormone to ensure that his body was receiving adequate thyroid hormone and told to return within 2 months for a follow-up evaluation of circulating thyroid hormone concentrations. He was also cautioned to carefully monitor his calcium intake. Respond to the following prompts about this case: 1. Define the bold terms in the text. (8 points) 2. Thyroid hormones exert their effects on cells in a manner similar to steroid hormones; describe the mechanism of action of thyroid hormones. ( 2 points) 3. Why would an imbalance in thyroid hormones have such widespread effects on the body? (2 points)
4. Why was goiter observed in Michael’s case? (2 points) 5. Why would calcium homeostasis be impaired in response to removal of the thyroid gland? (2 points) 6. Why could 131 I be used to specifically destroy the thyroid gland and have minimal effects on other cells and tissues in the body? (2 points) 7. Given that Michael and his wife may want to have more children, why was radioisotopic destruction of the thyroid gland ruled out? (2 points)

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