Absence of Malonyl Coenzyme A Decarboxylase in Mice Increases Cardiac Glucose Oxidation and Protect

5 roduit r nolan c alarcon c moore p barbeau a

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5. Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro- Augusto V, Przybykowski E, Morin J, Masse F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes . 2004;53: 1007–1019. 6. Rasmussen BB, Holmback UC, Volpi E, Morio-Liondore B, Paddon-Jones D, Wolfe RR. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J Clin Invest . 2002;110:1687–1693. 7. Dyck JR, Cheng JF, Stanley WC, Barr R, Chandler MP, Brown S, Wallace D, Arrhenius T, Harmon C, Yang G, Nadzan AM, Lopaschuk GD. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ Res . 2004;94:e78–e84. 8. Dyck JR, Lopaschuk GD. Malonyl CoA control of fatty acid oxidation in the ischemic heart. J Mol Cell Cardiol . 2002;34:1099–1109. 9. McGarry JD, Brown NF. The mitochondrial carnitine palmitoyltrans- ferase system: from concept to molecular analysis. Eur J Biochem . 1997; 244:1–14. 10. Awan MM, Saggerson ED. Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation. Biochem J . 1993;295(pt 1):61–66. 11. Saddik M, Gamble J, Witters LA, Lopaschuk GD. Acetyl-CoA car- boxylase regulation of fatty acid oxidation in the heart. J Biol Chem . 1993;268:25836–25845. 12. Kudo N, Barr AJ, Barr RL, Desai S, Lopaschuk GD. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5 -AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J Biol Chem . 1995; 270:17513–17520. 13. Yano S, Sweetman L, Thorburn DR, Mofidi S, Williams JC. A new case of malonyl coenzyme A decarboxylase deficiency presenting with car- diomyopathy. Eur J Pediatr . 1997;156:382–383. 14. McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED. Dichloroacetate prevents and reverses pulmonary hyper- tension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res . 2004;95:830–840. 15. Kuang M, Febbraio M, Wagg C, Lopaschuk GD, Dyck JR. Fatty acid translocase/CD36 deficiency does not energetically or functionally com- promise hearts before or after ischemia. Circulation . 2004;109: 1550–1557. 16. Dyck JR, Barr AJ, Barr RL, Kolattukudy PE, Lopaschuk GD. Character- ization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation. Am J Physiol . 1998;275(6 pt 2):H2122–H2129. 17. Stavinoha MA, RaySpellicy JW, Essop MF, Graveleau C, Abel ED, Hart-Sailors ML, Mersmann HJ, Bray MS, Young ME. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. Am J Physiol . 2004;287:E888–E895.
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  • Robert S Kiss
  • Fatty acid metabolism, McD

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