Colon and small intestine crohns disease and

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COLON AND SMALL INTESTINE. CROHN'S DISEASE AND ULCERATIVE COLITIS ARE THE PRINCIPAL TYPES OF INFLAMMATORY BOWEL DISEASE. 371
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THE CHARACTERISTIC HISTOLOGICAL FEATURES OF CROHN’S DISEASE ARE :- MUCOSAL INFLAMMATION THE EARLIEST LESION IN CROHN’S DISEASE APPEARS TO BE FOCAL NEUROPHILIC INFILTRATION INTO THE EPITHELIAL LAYER, PARTICULARLY OVERLYING MUCOSAL LYMPHOID AGGREGATES. 374
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AS THE DISEASE BECOMES MORE ESTABLISHED, NEUTROPHILS INFILTRATE ISOLATED CRYPTS. WHEN A SUFFICIENT NUMBER OF NEUTROPHILS HAVE TRAVERSED THE EPITHELIUM OF A CRYPT (BOTH IN SMALL AND LARGE INTESTINE) A CRYPT ABSCESS IS FORMED USUALLY WITH ULTIMATE DESTRUCTION OF THE CRYPT. 375
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INFLAMMATORY BOWEL DISEASE A 40 YEAR OLD MALE PRESENTS WITH CHRONIC DIARRHEA FOR ONE YEAR. ON INVESTIGATION, THE FINDINGS OBTAINED WERE CRYPT ABCESS, CRYPT ATROPHY, CRYPTITIS AND MUCOSITIS. MOST LIKELY DIAGNOSIS IS - (AIPGMEE 08) A) CROHN’S DISEASE B) ULCERATIVE COLITIS C) MICROSCOPIC COLITIS D) COLLAGENOUS COLITIS A 376
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THE PRESENCE OF ANTI-SACCHARAMYCES CEREVISAE ANTIBODY IS A SURROGATE MARKER OF ONE OF THE FOLLOWING - (AI 06) A) CELIAC DISEASE B) CROHN’S DISEASE C) ULCERATIVE COLITIS D) TROPICAL SPRUE 377
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378
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THE PRESENCE OF ANTI-SACCHARAMYCES CEREVISAE ANTIBODY IS A SURROGATE MARKER OF ONE OF THE FOLLOWING - (AI 06) A) CELIAC DISEASE B) CROHN’S DISEASE C) ULCERATIVE COLITIS D) TROPICAL SPRUE B 380
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ANTIBODY SHOWN TO BE USEFUL FOR CROHN’S DISEASE IS - (NBE/DNB PATTERN) A) OMALIZUMAB B) PALIVZUMAB C) NATALIZUMAB D) NONE OF THE ABOVE 381
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MEDICAL THERAPIES THAT ARE COMMONLY USED FOR TREATMENT OF CROHN’S DISEASE:- ORAL 5- AMINOSALICYLATES • ANTIBIOTICS • CONVENTIONAL GLUCOCORTICOIDS • NON SYSTEMIC GLUCOCORTICOIDS 382
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IMMUNOMODULATORS: - AZATHIOPRINE - 6-MERCAPTOPURINE - TACROLIMUS - CYCLOSPORINE - SIROLIMUS BIOLOGICAL THERAPIES: - INFLIXIMAB - ADALIMUMAB 383
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NATALIZUMAB IS A MONOCLONAL ANTIBODY SHOWN TO BE USEFUL FOR CROHN’S DISEASE. NATALIZUMAB  CROHN S DISEASE PALIVIZUMAB  RSV OMALIZUMAB  BROCHIAL ASTHMA 384
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ANTIBODY SHOWN TO BE USEFUL FOR CROHN’S DISEASE IS - (NBE/DNB PATTERN) A) OMALIZUMAB B) PALIVZUMAB C) NATALIZUMAB D) NONE OF THE ABOVE C 385
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DRUG USED IN THE TREATMENT OF ULCERATIVE COLITIS A/E- A) CORTICOSTEROIDS (NEET/DNB PATTERN) B) 5 ASA C) SULFASALAZINE D) METHOTREXATE 386
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MANAGEMENT OF ULCERATIVE COLITIS:- THE MAINSTAY OF THERAPY FOR MILD TO MODERATE ULCERATIVE COLITIS IS SULFASALAZINE AND OTHER 5 ASA AGENTS. SULFASALAZINE IS A PREPARATION OF 5AMINOSALICYLIC ACID. IT CONSISTS OF TWO COMPOUNDS: - SULPHAPYRIDINE AND - 5- AMINOSALICYLIC ACID. THE PROBLEM WITH THIS PREPARATION WAS SIGNIFICANT ADVERSE EFFECTS WHICH WERE ATTRIBUTED MAINLY TO SULPHAPYRIDINE.
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  • Winter '16
  • jean grey
  • chronic hepatitis, chronic liver failure

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