Brca1 and brca2 mutations can influence the risk for

  • No School
  • AA 1
  • 63

This preview shows page 10 - 16 out of 63 pages.

BRCA1 and BRCA2 mutations can influence the risk for multiple cancer types including breast, ovarian, prostate, and skin (i.e., melanoma). Challenges in Reviews of Genetic Tests (3 of 6) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
Image of page 10
Time Lag This term refers to the time difference between genetic testing and clinically important events. Sufficient duration of studies is important in evaluating studies of genetic tests. It should be determined if subjects have reached the age beyond which clinical expression would be likely. Challenges in Reviews of Genetic Tests (4 of 6) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
Image of page 11
Other Challenges Direct evidence for the impact of genetic test results on health outcomes is often lacking. The evidence base is too limited in scope. It is difficult to find published information on various aspects of genetic tests, particularly analytic validity. There are several technical issues that are relevant to assessment of analytic validity. These issues: Differ according to the type of test May influence interpretation of results May differ, depending on the specimen being tested (e.g., different considerations when assessing tumor genomes vs. human genomes) Challenges in Reviews of Genetic Tests (5 of 6) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
Image of page 12
Other Challenges ( Continued ) Difficulties can arise when determining susceptibility or risk in asymptomatic individuals. Utility of a test may depend on the ability of individuals to report and identify certain clinical factors. Statistical issues must also be taken into account. Genetic test results often are derived from analytically complex studies that have undergone a very large number of statistical tests. Challenges in Reviews of Genetic Tests (6 of 6) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
Image of page 13
Background on Genetic Tests Challenges in Reviews of Genetic Tests Principles for Addressing the Challenges Illustrative Examples General Overview: Section 3 Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
Image of page 14
1.
Image of page 15
Image of page 16

You've reached the end of your free preview.

Want to read all 63 pages?

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes
A+ icon
Ask Expert Tutors