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Lecture_16_-Gases

Arginine o2 to no arginine can come from the diet

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arginine + O2 to NO - arginine can come from the diet; want more NO? Eat more arginine -Arginine + Citruilline supplements toted as better than arginine alone. Promoting NO Synthesis You cannot put a gas in a pill! This is arginine!
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Promoting NO signaling 1) Hyperactivation of NMDA receptors 2) Inhibition of cGMP breakdown Viagra, Cialis, Levitra: cGMP- specific phosphodiesterase type 5 inhibitor -relaxation of vasculature, increased blood flow….but it’s not via a direct effect on NO per se but prolongs NO signaling when activated PDE
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Inhibiting NO Signaling - CAPON (carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase) is a newly discovered protein that binds to NOS and prevents its ability to associate with PSD- 95 no close association with NMDA receptor no activation by CaMK because it’s not anchored -CAPON is over-expressed in the PFC of schizophrenia patients and the gene is localized to a region of chromosome 1 highly associated with schizophrenia in linkage studies.
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Gases: Carbon Monoxide - CO is generated in neurons by heme oxygenase (HO) , which degrades heme to biliverdine, iron and CO -3 isoforms of HO (HO1-3), with HO2 enriched in neurons -CO freely diffuses out of neurons and stimulates guanylyl cyclase, leading to the formation of cGMP PKG -CO regulation is not well-understand but believed to be controlled by PKC activity (i.e., activation of Gq receptors like Group1 mGluRs) or by phorbol esters , which lead to the direct activation of HO2 by casein kinase2 (CK2); may also be activated by Ca2+/calmodulin kinase -may play a role in circadian rhythms as found to influence DNA binding of key circadian transcription factors
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arginine O2 to NO arginine can come from the diet want more...

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