and incidental depression are associated with increased mortality Case study Patients developed additional diseases during period such as DM III Hybels, C., Pieper, C., Payne, M., & Steffens, D. (2016). Late-life depression modifies the association between cerebral white matter hyperintensities and functional decline among older adults. The American Journal of Geriatric Psychiatry , 24 (1), 42-49. gp.2015.03.001 Health Older pts with cerebrovas cular risk factors AND depression are at higher risk for functional decline RCT Ability to follow pts for 16 years and observe decline, if any I Jokela, M., Virtanen, M., & Batty, D. (2016). Inflammation and specific symptoms of depression. JAMA Psychiatry , 73 (1), 87-88. apsychiatry.2015.1977 Health Inflammati on is associated with variety of depression symptoms, such as tiredness, lack of energy, sleep disturbance s, appetite changes Data collecti on, cross section al survey Inflamma tory markers also associated with sickness symptoms , which are similar to depressio n symptoms . More research needed to determine if inflammat IV
Citation Concept ual Framew ork/ Theory Main Finding Resea rch Metho d Strength s of Study Weakne sses Level of Evide nce ory markers can indicate depressio n symptoms Lerche, S., Gutfreund, A., Brockmann, K., Hobert, M., Wurster, I., Sunkel, U., ... Berg, D. (2018). Effect of physical activity on cognitive flexibility, depression and RBD in healthy elderly. Clinical Neurology and Neurosurgery , 165 , 88-93. neuro.2018.01.008 Health Physical exercise increases cognitive flexibility, improves depressive symptoms and sleep Cross section al Study completed with neurologi cally healthy individual s II Liu, L., Gou, Z., & Zuo, J. (2014).
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