The advantages of soft gelatin capsule : • Soft gels are easy to swallow, once swallowed, release their contents very quickly. • have the ability to mask odors and unpleasant tastes • have an elegant appearance • readily dissolve in the gastric juices of the digestive tract • they may enhance the bioavailability of the active ingredient • In specialized dosage form, soft gel can be made into chewable, extended release, captabs, etc. It can also be used for ophthalmic preparations, e.g. aplicaps, vaginal/rectal suppositories. • Dosage Accuracy. Uniformity and precision dosage • Product Security. Dosage and formulation are tamper-resistant (a punctured or tampered softgels will leak or become discoloured). Protection against counterfeit • Product Stability. Sealed container, Protection from light for photosensitive formulations, Protects drug from oxidation and degradation Soft gel also had some disadvantages point : 9,10 • water soluble material are difficult to incorporate • Highly moisture sensitive. Gelatin is extremely water soluble, which helps it dissolve in the body. The downside is that soft gelatin capsules are very sensitive to heat and humidity. In hot or humid climates, soft gel caps may stick together or even break open before you have a chance to use them. Keeping your soft capsules in the bathroom may also decrease their life expectancy, since showers create a hot, humid climate that may not dissipate quickly. • Efflorescent material can not be incorporated, they may cause softening/leaching • Deliquescent materials cannot be incorporated. They may cause hardening or brittle capsule. • More Costly. Many pharmaceutical companies do not have the equipment necessary to fill soft gelatin capsules and have to transport the drugs to have them processed, adding to the cost. This cost can increase the price the consumer pays. Certain health supplements, such as cod liver oil, come in liquid and soft gel cap form. In most cases, the price is greater for the soft capsules than for the liquid. • Dietary Restrictions. Gelatin is traditionally made out of the bones and skins of pigs and cows. Many groups, however, have dietary proscriptions that prevent them from consuming animal products found in soft gelatin capsules. Soft gel caps violate the religious dietary restrictions of observant Jews, Muslims, Buddhists and Hindus. Because soft capsules are made out of animal parts, many vegetarians also opt not to use them. There are animal-free substitute gelatin capsules made out of seaweed extract or other sources, but they are generally more expensive and harder to find.
Avalabile online at B.Srividya et al; Int.J.Pharm Drug Anal Vol: 2 Issue:9 Page:727-733 731 Ideal characteristics of soft capsules: • To optimize the chemical stability of the active compound.
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- Fall '19
- Gelatin, softgel, Hard Capsules