Venous Thromboembolism (VTE) Fall 2012

Venous circulatory system deep veins upper

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Venous Circulatory System: Deep Veins Upper Extremities Lower Extremities Brachial Axillary Subclavian Superior Vena Cava Peroneal Posterior Tibial PoplitealSuperficial Femoral Vein Common Femoral Vein Iliac Inferior Vena Cava
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Epidemiology ~50% have symptomatic VTE 350,000-600,000 are hospitalized 100,000 die
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Pathophysiology: Virchow’s Triad The American Society of Hematology. http://www.hematology.org/Publications/Hematologist/2008/1307.aspx Accessed Nov. 5, 2012.
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Pathophysiology: Virchow’s Triad Venous Stasis Vascular Injury Major surgery Immobility Paralysis Spinal cord injury S/p CVA Obesity Varicose veins Polycythemia vera Cardiac dysfunction Heart failure S/p MI Trauma Orthopedic surgery Knee replacement (TKR) Hip replacement (THR) Indwelling IV catheters
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Risk Factors: Hypercoagulable States Inherited Acquired Genetic mutation Prothrombin G20210A Factor V Leiden Activated protein C resistance Protein C deficiency Protein S deficiency Antithrombin deficiency Malignancy Antiphospholipid antibody syndrome Lupus anticoagulant Anticardiolipid antibodies Pregnancy Post-partum Estrogen Nephrotic syndrome
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Venous Circulatory System Deep Veins Upper Extremities...

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