41 cytoplasmic enzymes alanine aminotransferase alt

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41
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CYTOPLASMIC ENZYMES - - ALANINE AMINOTRANSFERASE (ALT) - CYTOPLASMIC ISOMER OF ASPARTATE AMINOTRANSFERASE (AST) THESE ENZYMES ARE LOCATED IN THE CYTOPLASM. ELEVATION OF THESE ENZYMES IN THE PLASMA REFLECT CELL INJURY. 42
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MITOCHONDRIAL ENZYMES: - MITOCHONDRIAL ISOMER OF ASPARTATE AMINO TRANSFERASE THESE ENZYMES ARE ALSO SITUATED IN THE CYTOPLASM (MITOCHONDRIA) ELEVATION OF THIS ENZYME ALSO REFLECTS CELL INJURY, IT IS RELEASED PRIMARILY WITH MITOCHONDRIAL INJURY AS CAUSED BY ETHANOL INGESTION. 43
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CANALICULAR ENZYMES - - ALKALINE PHOSPHATASE - GAMMA GLUTAMYL TRANSFERASE THESE ENZYMES ARE INCREASED WHEN THERE IS CANALICULAR OBSTRUCTION (OBSTRUCTIVE JAUNDICE). GAMMA GLUTAMYL TRANSFERASE IS ALSO INCREASED BY EXPOSURE TO ENZYME INDUCING DRUGS. IT IS ELEVATED IN 60% TO 70% OF THOSE WHO CHRONICALLY ABUSE ALCOHOL. 44
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ABNORMAL EXCRETORY FUNCTION OF HEPATOCYTES ASSESSED BY- (PGI JUNE 07) A) INCREASED PT B) INCREASED ALT C) INCREASED ALKALINE PHOSPHATASE D) INCREASED GAMMA GT C, D 45
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5’-NUCLEOTIDASE ACTIVITY IS INCREASED IN- (AI05) A) BONE DISEASES B) PROSTATE CANCER C) CHRONIC RENAL FAILURE D) CHOLESTATIC DISORDERS D MOST IMPORTANT ENZYMES REFLECTING CHOLESTASIS . ALKALINE PHOPHATASE . 5’NUCLEOTIDASE . GAMMA GLUTAMYL TRANSPEPTIDASE 46
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WHICH OF THE FOLLOWING ENZYME ASSAY IS USEFUL TO DIAGNOSE ALCOHOLISM - (AIIMS DEC 99) A) SGOT B) SGPT C) ALKALINE PHOSPHATASE D) GLUTAMYL AMINOTRANSFERASE A,B,D 47
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IN ALCOHOLIC LIVER INJURY PRIMARILY MITOCHONDRIAL ISOMER OF AST IS ELEVATED WHEREAS IN OTHER CAUSES OF LIVER INJURY PRIMARILY CYTOPLASMIC ISOMER OF ASPARTATE AMINO TRANSFERASE IS ELEVATED . THE HALF LIFE OF MITOCHONDRIAL AST IS MUCH LONGER THAN THE HALF LIFE OF CYTOPLASMIC AST. 48
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GAMMA GLUTAMYL TRANSFERASE – GAMMA GLUTAMYL TRANSFERASE IS A CANALICULAR ENZYME THEREFORE IT SHOULD NORMALLY BE ELEVATED IN CASES OF CANALICULAR OBSTRUCTION. THEN WHY THIS ENZYME IS ELEVATED IN CASES OF ALCOHOLIC LIVER INJURY WHERE THERE IS NO CANALICULAR OBSTRUCTION. THE REASON IS THAT GAMMA ELUTAMYL TRANSFERASE BESIDES BEING INCREASED IN CANALICULAR OBSTRUCTION, IS ALSO INCREASED BY ENZVME INDUCING DRUGS SUCH AS ETHANOL. ALKALINE PHOSPHATASE LEVEL MAY ALSO INCREASE IN ALCOHOLIC LIVER DISEASE. 50
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A 40 YEAR MALE HAVE H/O JAUNDICE & ASCITES. HE IS A WELL KNOWN ALCOHOLIC. TRUE STATEMENT IS/ARE: A) AST/ALT <2 B) PMN >5500/P L C) INCR. S.LDH D) DECR. LIVER SPAN E) INCR. S.ALP (PGI 09) 51
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A 40 YEAR MALE HAVE H/O JAUNDICE & ASCITES. HE IS A WELL KNOWN ALCOHOLIC. TRUE STATEMENT IS/ARE: A) AST/ALT <2 B) PMN >5500/P L C) INCR. S.LDH D) DECR. LIVER SPAN E) INCR. S.ALP (PGI09) B,E 54
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WHICH ONE OF THE FOLLOWING SERUM LEVELS WOULD HELP IN DISTINGUISHING AN ACUTE LIVER DISEASE FROM CHRONIC LIVER DISEASE - (AI05) A) AMINOTRANSAMINASE B) ALKALINE PHOSPHATASE C) BILIRUBIN D) ALBUMIN 55
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THE LIVER IS THE SITE OF SYNTHESIS FOR MOST PLASMA PROTEINS.
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  • Winter '16
  • jean grey
  • chronic hepatitis, chronic liver failure

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