Antiemetics decreased incidence and severity of

Antiemetics; decreased
incidence and severity of
nausea and vomiting
following chemotherapy
Blocks the effects of
serotonin at 5-HT3
receptor sites
(selective
Prevention of nausea
and vomiting associated
with highly or
moderately emetogenic
Serotonin syndrome,
headache, dizziness,
drowsiness, fatigue,
weakness, torsade
Monitor ECG in patients wit h hypokalemia,
hypomagnesemia, HF, bradyarrhythmias,
or patients taking concomitant
medications that prolong the QT interval;

or surgery
antagonist) located
in vagal nerve
terminals and the
chemoreceptor
trigger zone in the
CNS
chemotherapy;
de pointes, QT
interval
prolongation,
constipation,
diarrhea, abdominal
pain, dry mouth,
increased liver
enzymes,
extrapyramidal
reactions, stevens-
johnson syndrome,
toxic epidermal
necrolysis
monitor for signs and symptoms of
serotonin syndrome, assess for rash
Metoclopramide/
Reglan
Antiemetics
Blocks dopamine
receptors in
chemoreceptor
trigger zone of the
CNS; stimulates
motility of the upper
GI tract and
accelerates gastric
emptying
Used in conjunction
with an opioid to
prevent or treat emesis
Drowsiness,
extrapyramidal
reactions,
restlessness,
neuroleptic
malignant
syndrome, anxiety,
depression,
irritability, tardive
dyskinesia,
arrhythmias
(supraventricular
tachycardia,
bradycardia),
hypertension,
hypotension,
constipation,
diarrhea, dry mouth,
nausea,
gynecomastia,
methemoglobinemia
, neutropenia,
leukopenia,
agranulocytosis
Monitor for neuroleptic malignant
syndrome (hyperthermia, muscle rigidity,
altered consciousness, irregular pulse or
BP, tachycardia, and diaphoresis)l
Doxylamine-
pyridoxine/ Diclegis
Antiemetics; decreased
nausea and vomiting
associated with
pregnancy
Combination of an
antihistamine and a
vitamin B6 analog
Treatment of nausea
and vomiting during
pregnancy that has not
responded to
conservative
management
Drowsiness
Assess for frequency and amount of
emesis daily during therapy.
Monitor hydration status to prevent
dehydration
Methotrexate/ Trexall Antimetabolites;
antineoplastics;
antiheumatics;
immunosuppressants
Interferes with folic
acid metabolism
Dissolves ectopic
pregnancies; treatment
of: trophoblastic
neoplasms, leukemias,
breast carcinoma, head
carcinoma, neck
carcinoma, lung
carcinoma
Arachnoiditis,
dizziness,
drowsiness,
headache, malaise,
seizures, blurred
vision,
dysarthriatransient
blindness,
pulmonary fibrosis,
interstitial
pneumonitis,
hepatotoxicity,
anorexia, diarrhea,
nausea, stomatitis,
vomiting, acute
renal failure,
infertility, erythema
multiforme, stevens-
johnson syndrome,
toxic epidermal
necrolysis, alopecia,
painful plaque
Methotrexate dissolves ectopic
pregnancies by destroying rapidly dividing
cells

erosions,
photosensitivity,
pruritus, rashes, skin
ulceration, urticarial,
aplastic anemia,
anemia, leukopenia,
thrombocytopenia,
hyperuricemia,
osteonecrosis, stress
fracture,
nephropathy, chills,
fever, soft tissue
necrosis
Clomiphene / Clomid Ovulation inducer
Stimulates release
of pituitary
gonadotropins,
follicle-stimulating
hormone, and
luteinizing hormone,
resulting in
ovulation and the
development of the
corpus luteum
Induces ovulation in
anovulatory women
who desire pregnancy.