296 in which of the following conditions of

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296
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IN WHICH OF THE FOLLOWING CONDITIONS OF MALABSORPTION, AN INTESTINAL BIOPSY IS DIAGNOSTIC - ( AIIMS MAY 05) A) CELIAC DISEASE B) TROPICAL SPRUE C) WHIPPLE’S DISEASE D) LACTOSE INTOLERANCE C 297
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Q- WHIPPLE’S DISEASE MOST COMMON CNS MANIFESTATION OF WHIPPLE’S DISEASE IS - (AI 99) A) CEREBELLAR ATAXIA B) SUPRANUCLEAR OPHTHALMOPLEGIA C) SEIZURE D) DEMENTIA 298
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WHIPPLE’S DISEASE IS A RARE DISEASE CAUSED BY THE BACTERIUM TROPHERYMA WHIPPELI. IT IS A SYSTEMIC CONDITION THAT MAY INVOLVE ANY ORGAN OF THE BODY BUT PRINCIPALLY AFFECTS THE - INTESTINE - CENTRAL NERVOUS SYSTEM - JOINTS 299
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CLINICAL FEATURES – THE ONSET OF WHIPPLE’S DISEASE IS INSIDUOUS AND IT IS CHARACTERIZED BY :- DIARRHOEA STEATORRHEA ABDOMINAL PAIN WEIGHT LOSS MIGRATORY LARGE JOINT ARTHROPATHY . FEVER 300
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OPHTHALMOLOGIC AND CENTRAL NERVOUS SYSTEM SYMPTOMS. DEMENTIA IS A RELATIVELY LATE SYMPTOM AND IS AN EXTREMELY POOR PROGNOSTIC SIGN. 301
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COMMON FINDING ARE: - I) SUPRANUCLEAR OPHTHALMOPLEGIA II) PROGRESSIVE DEMENTIA & COGNITION CHANGES III) ALTERED LEVEL OF CONCIOUSNESS 302
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LESS COMMON FINDING ARE: - PSYCHIATRIC SYMPTOMS, HYPOTHALMIC MANIFESTIONS (I.G., POLYDIPSIA, HYPERPHAGIA, INSOMNIA), CRANIAL NERVE ABNORMALITIES, NYSTAGMUS, SEIZURES & ATAXIA. 303
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DIAGNOSIS:- THE DIAGNOSIS OF WHIPPLE’S DISEASE IS SUGGESTED BY A MULTISYSTEM DISEASE IN A MAN WITH DIARRHOEA AND STEATORRHOEA. THE PRIMARY APPROACH TO ESTABLISH DIAGNOSIS IN THESE CASES IS TO OBTAIN TISSUE BIOPSIES FROM SMALL INTESTINE. 304
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ON BIOPSY THE HALLMARK OF WHIPPLE’S DISEASE IS THE PRESENCE OF DISTENDED MACROPHAGES WITHIN THE SMALL INTESTINE MUCOSA. THESE MACROPHAGES CONTAINS PAS POSITIVE DIASTASE RESISTANT GRANULES AND ROD SHAPED MICRO ORGANISM. 305
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Q- WHIPPLE’S DISEASE MOST COMMON CNS MANIFESTATION OF WHIPPLE’S DISEASE IS - (AJ 99) A) CEREBELLAR ATAXIA B) SUPRANUCLEAR OPHTHALMOPLEGIA C) SEIZURE D) DEMENTIA B 306
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WHICH OF THE FOLLOWING IS A HISTOLOGICAL FEATURE OF WHIPPLE’S DISEASE- (AIPGMEE 08) A) INFILTRATION OF HISTOCYTES IN THE LAMINA PROPRIA B) GRANULOMA IN THE LAMINA C) MACROPHAGES WITH PAS (+) MATERIAL INSIDE THE LAMINA PROPRIA D) EOSINOPHILS IN THE LAMINA PROPRIA C 307
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CELIAC DISEASE COELIAC DISEASE, ALSO SPELLED CELIAC DISEASE, IS AN AUTOIMMUNE DISORDER AFFECTING PRIMARILY THE SMALL INTESTINE THAT OCCURS IN PEOPLE WHO ARE GENETICALLY PREDISPOSED. COELIAC DISEASE IS CAUSED BY A REACTION TO GLUTEN, WHICH ARE VARIOUS PROTEINS FOUND IN WHEAT AND IN OTHER GRAINS SUCH AS BARLEY, AND RYE. 308
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CELIAC SPRUE CELIAC SPRUE INVOLVES THE PROXIMAL PORTION OF SMALL INTESTINE AS THIS PORTION IS MAXIMALLY EXPOSED TO THE GLIADIN PROTEIN, THIS IS THE REASON FOR IRON DEFICIENCY ANEMIA IN CELIAC DISEASE (IRON IS ABSORBED MAXIMALLY FROM DUODENUM).
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  • Winter '16
  • jean grey
  • chronic hepatitis, chronic liver failure

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