o Referred to it as celiac disease Cause was unknown until WWII Dutch Dr Willem

O referred to it as celiac disease cause was unknown

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o Referred to it as celiac disease - Cause was unknown until WWII – Dutch Dr. Willem. K. Dicke o Germans tried to starve the Dutch by cutting off shipments, including wheat Noticed that patients suffering from celiac disease suddenly got better when supply was off - Celiac’s often shows up early in life, but can take years for correct diagnosis o Environmental factors can trigger it Stressful events (surgery/childbirth) Viral infections - 1 in 100 people affected Wheat contains family of proteins called GLUTEN o Two basic proteins in gluten 1) Gliadin the REAL problem in celiac disease 2) Glutenin HOW DOES CELIAC’S HAPPEN? o Immune system mistakes gliadin as invader antibody attack Triggers release of cytokines , damaging the villi in small intestine (where absorption of food actually occurs) - Small Intestine o Villi: large surface area = easier nutrient absorption o But in celiac’s , villi inflame and FUSE together impairment to absorption Stool = light colored, bulky, smelly bc of HIGH FAT content not absorbed Poor absorption of iron, folic acid, calcium and protein WHEN TO SUSPECT CELIAC’S? o In Children: persistent diarrhea, stunted growth o Adults: unexplained weight loss DIAGNOSIS o Endoscopic Biopsy: take a sample in small intestine to see if villi fused together o Blood tests for anti-gliadin antibodies But only 50% show damaged villi even if tested positive o Anti-tissue transglutaminase test - May be linked to NON-HODGKIN’S LYMPHOMA - Can be connected to osteoporosis, behavioral/neurological problems and AUTISM! Silent Celiac Disease - 1 in 200 people - NO Symptoms o BUT positive blood test and biopsy - Controversy: eventually will develop celiac’s o Preventative gluten-free diet usually recommended just in case Latent Celiac Disease - Endoscopy biopsy is NEGATIVE - Blood test is POSITIVE - NO symptoms - Don’t need to go on gluten-free diet Watchful Waiting
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Non-Celiac Gluten Sensitivity - 6-10% of the population - Feel better when gluten-free diet but they test NEGATIVE in both tests Lesson 2: Adverse Food Reactions II VIDEO #1 Classical Food Allergy - Give rise to antibodies Anaphylaxis : total collapse of circulatory system lead to death What happens in an Allergy? - Body’s immune system thinks a substance is foreign and attacks it o Generates antibodies which will try to get rid of the allergen Thus manifesting an allergic reaction Most Allergenic Foods : Milk, nuts, eggs, shellfish, fish **NO ONE is allergic upon FIRST exposure: only when antibodies form ** SUBSEQUENT exposure: allergen-antibody reaction Can people get a reaction if they kiss someone who ate peanuts? NO EpiPen = adrenaline = needs to be within reach Hypoglycemia (Low Blood Sugar) - Diagnosis: o GIVE A SUGAR SOLUTION, THEN BLOOD IS DRAWN PERIODICALLY TO TEST FOR SUGAR Hypoglycemia: if sudden drop in blood sugar after 30 mins – 2 hrs - Solution: o Small meals to spread out carb intake - Myths o Sugar causes hyperactiivity NO, kids are hyper cuz of the situation Simple Carbs (Sugar) CALMING effect - Amino acids absorbed into either the 1) brain 2) muscle tissue o
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