The Impact of Age on Pharmacotherapy When prescribing medications to patients of advanced age (the elderly), providers typically prescribe NSAIDs in smaller doses and with shorter half-lives than they would for younger adults. Patients older than 65 years of age are deemed to be at risk for developing gastro-intestinal (GI) hemorrhage and should be treated with either a combination of a gastric protectiveagent or a proton pump inhibitor and a nonselective NSAID or a COX-2 inhibitor (Arcangelo, et al., 2017).Measures Used to Reduce Negative Side EffectsWhen prescribing medications to patients of any age, providers must consider the risks, benefits, contraindications, adverse reactions, drug-drug interactions, drug-food interactions, mechanisms of action, and cautious use recommendations. When prescribing medications to elderly patients, providers must consider physiological, biological, and cognitive changes that occur as one ages regarding administration, metabolism, distribution, absorption, and eliminationof medications prescribed. By embracing both pharmacokinetic and pharmacodynamic principles of pharmacotherapy when prescribing medications, providers can reduce negative sideeffects experienced by their patients.References
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