Stimulate other biologic phenomena such as activating complement binding Fc

Stimulate other biologic phenomena such as activating

This preview shows page 90 - 93 out of 248 pages.

Stimulate other biologic phenomena such as activating complement & binding Fc receptors on other lymphoid cells Mediate anaphylaxis, atopic allergies, serum sickness, and arthus reactions Structure : Consist of two heavy chains & two light chains Heavy chain contributes to both Fc and Fab fragments Light chain only contributes to Fab Fab (Antibody)  Contains Antigen binding site  Area from the Hinge region and up  Hypervariable Region  Ag binding to the Fab is noncovalent Fc (Cell)  The Stem of the “Y” 90
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 Binds to the Phagocytes , Mast cells, Basophils, Eosinophils, etc.  Think C Constant, Carboxy, Complement binding, and Carbohydrate side chains The variable part  V H and V L (amino terminal side) recognizes the antigens Constant regions  In IgG and IgM, it fixes complement  Carboxyl terminal side Disulfide Bonds Between 2 Heavy Chains Between Heavy and Light Chains Ig Epitopes Allotype (polymorphism) Ig epitope that differs among members of same species Can be on light or heavy chain Isotype (IgG, IgA,etc.) Ig epitope common to a single class of Ig (five classes, determined by heavy chain) An immune cell posseses IgM and IgD on its cell surface…which of the following differs between them?  Heavy Chain Variable - V H Idiotype (specific for an antigen) Ig epitope determined by antigen-binding site Think “Idio” are unique Immunoglobulin functions (condensed): IgG : Opsonization, Placental passage, Complement activation , 2ndary Response IgA : Mucosal (secretory) immunity, prevents attachment, Gets secretory portion from epi cells first IgM : Complement activation , 1ary Response, does NOT cross placenta, Ag receptor on B cells IgE : Basophil & mast cell sensitization, Type I hypersensitivity, Immunity to worms IgD : Antigen triggering of B cells Ig Isotypes (detailed): IgG : Most abundant Only Ig that crosses the placenta Activates complement Predominant serum Ig found during a memory response Main defense against various pathogenic organisms As the severity of Periodontal Disease increases, there is an increase in plasma cells that produce IgG Secondary or amanestic response to protein antigen  Characterized by production of IgG Ab/s with High Titer T 1/2 = 1 month Where is it activated???? IgA : 91
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2 nd most abundant  Remember that IgA produces more than all of the others combined, but SHORT half life, that is why IgG is most abundant Polymeric IgA  Present in body secretions, such as (saliva, tears, breast milk, especially colostrums) Protects surface tissues Synthesized by plasma cells in
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