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The cure is only 50% with prolonged therapy. C.Fluconazole: Azole Drug Classe.MOA: same as above (for superficial and system mycosis)f.Uses: oral therapy for vulvovaginal candidias, oropharyngeal candidias, and onychomocosis (fungal infection of toenail). For treating ongoing infection 150mg onceFor recurrent 150mg/week for 6 monthsFor oropharyngeal candidias 200mg on day and 1 mg followed after for 2 weeks D.Voriconazole: g.MOA: same as aboveh.Uses: for life threatening fungal infections. Like other drugs inhibits cytochrome P450. It is active against broad spectrum fungal infections especially for candidemia (fungal infection in blood), invasive asperilosis (usually lung), esophageal candidiasis, serous infections and according to the Infectious dz society of America, it has replaced Amphotericine B for aspergilosisE.Explain what -azole antifungal drugs are and give examples; also, recognize that these drugs, when given systemically, can be a major cause of interactions with other drugs by inhibiting their hepatic metabolism. Identify which drugs treat aspergillosis and/or candidiasis. Identify which drugs are used in caution with certain health conditions and renal/hepatic disease..