H nmr was also used to determine the intermediate of

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H NMR was also used to determine the intermediate of the musk ketone synthesis. Four important peaks occurring at 1.322 ppm, 2.342 ppm, 2.493 ppm, and 7.054 ppm were characterized. The single peak at 1.322 ppm indicates that this is representative of the 9 identical hydrogens found on the isopropyl group of the molecule. The peak at 2.493 ppm is split only once and represents the three equivalent hydrogens that occur on the ketone group. The 2.342 ppm peak is indicative of the six equivalent hydrogens of the two attached methyl groups to the benzene ring. Lastly, the peak occurring at 7.054 ppm represents the two equivalent hydrogens that are attached directly to the ring structure. However, small peaks are also witnessed within the obtained H NMR and indicate that left over starting material may have reacted with the various added substrate. The experiment itself could have been improved in many ways. The extremely low percent yields of 13.67%, 7.41%, and 0.68% for the respective intermediates and the final product is most likely due to the reacting of starting material with substituents as outlined above as well as human error. Human error was the largest source for failure of the end product to solidify. For example the water valve for the condenser was not turned on during the first
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addition of AlCl 3 to the reaction mixture. Also the hose popped off the valve therefore a small amount of water could have gotten into the AlCl 3 beaker. Another possible source for error is that the measurement of specific reactants and materials during the lab procedure might not have been as precise as needed for the synthesis of the correct product. Not all of the reaction material was transferred to the large separatory funnel during the first week of the experiment. Thus, extra meta-xylene was used to get as much product into the desired separatory funnel as possible. This could have also contributed to the low obtained percent yield. Lastly, the AlCl 3 that was added to the reaction material was a light yellow color which indicates that is could have possibly absorbed some water. In order to improve the result of this lab fresh AlCl 3 should be used. References: 1 Basu, U. "The Grignard Reaction." 5 Mar. 2013. Lecture. 2 Huston, Ericka, and Chong Liu. Organic Chemistry 1 Laboratory Manual. Plymouth: Hayden McNeil, 2011. Print. 3 Padias, Anne B. Making Connections: A How to Guide for Organic Chemistry Lab Techniques . 2 nd ed. Plymouth: Hayden-McNeil, 2011. Print. Integrity Statement: I submit this lab report as an original document. I assert that all ideas and discussions of data contained herein is my own work, unless otherwise referenced. Jokes:
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  • Fall '07
  • crandall
  • Organic chemistry, pH, Benzene, final product, Sulfuric acid, Electrophilic aromatic substitution, Friedel-Crafts Acylation, musk ketone

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