7.Liraglutide (Victoza) in an incretin mimetic similar to exenatide that has been associated with___________? 1. Dapagliflozin (Farxiga-far-SEE-guh) and Canagliflozin (Invokana) are SGTLT 2 inhibitors. What is the MOA? These new adgents increase glucose excretion in the urine by inhibiting sodium- glucose co-transporter 2 (SGLT2) in the kidney 2.What are the adverse effects of the SGTLT2inhibitors?
1.Pramlintide (Symlin) is an injectable amylin analog used with insulin that prolongs gastric emptying time to decrease postprandial glucose. It should not be used in patients with________? 2.What is the boxed warning on pramlintide (Symlin)? 3.Name a cholesterol lowering drugs that is approved to treat DM 4.Which drugs are used to treat diabetic peripheral neuropathy? 5. Drugs that influence blood sugar Alcohol – paralyzed livr's ability to breakdown glucagon and increase blood sugar leading to hypoglycemia Beta blockers – mask s/s of hypoglycemia and impair glycogenolysis Statins – increase blood sugar Sulfonylureas Meglitinides Glucocorticoids Antipsychotics Quiz Questions: 1. Glucagon is used to treat: Answer: Hypoglycemia 2.Dan, age 45, is obese and has type 2 diabetes and has been having trouble getting his glycohemoglobin under control. He's heard the Exenatide (Byetta) causes weight loss andwants to try it. What do you tell him? 3. Marie, age 50, has diabetes and checks her blood glucose level several times a day. Her blood glucose level ranges from 250-280 mg/dL in the morning and is usually about 100 at bed time, In the morning she takes 30 units of NPH and 4 units of regular insulin, and before dinner takes 18 units of NPH and 4 units of regular. Although she has had her insulin dosage adjusted several times in the past month, it has had no effect on her high morning blood glucose level. What is your next course of action? 10
Answer: Have her check her blood glucose level between 2-4:00 AM for the next several days 4. Your patient with diabetes ask you about indulin glargine (Lantus). You would tell her that Answer: Lantus stays in your system for 24 hours 5. Harriet, age 62, has type 1 diabetes that is well controlled by insulin. Recently, she has been having marital difficulties that have left her emotionally upset. As as result of this stress, it is possible that she will Answer: Have an increased blood sugar level 6. Which class of drugs used to treat diabetes can cause excessive GI symptoms such as flatulence Answer: Alpha-glucosidase inhibitors (Precose and Glyset)
- Spring '14
- blood glucose, Blood sugar