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MIC 101 Exam 1 Winter 2013

The therapeutic dose for a chemotherapeutic agent is

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45. The Therapeutic Dose for a Chemotherapeutic Agent is -- A. • The Ratio of the Toxic Dose to the Therapeutic Dose. • Anti-Bacterial Chemotherapeutic Agents generally have a High Therapeutic Index. B. • The Ratio of the Therapeutic Dose to the Toxic Dose. • Anti-Parasitic Chemotherapeutic Agents generally have a High Therapeutic Index. C. • The Level that if maintained over a Period of Time will result in the Control or Elimination of a Bacterium. • Anti-Bacterial Chemotherapeutic Agents generally have a High Therapeutic Index. D. • The Level that if maintained over a Period of Time will result in Damage to the Host. • Anti-Parasitic Chemotherapeutic Agents generally have a High Therapeutic Index. STOP! Check it again!
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MIC 101 Exam 1 Page 28 46. Which of the following Groupings of Statements is most Correct? A. • Penicillin inhibits Transpeptidation by binding to Penicillin- Binding Proteins (PBPs) and preventing their Transpeptidase Activity • Vancomycin Inhibits Transpeptidation by binding to D-Alanine- D-Alanine of Pentapeptide Side Chains of Peptidoglycan Precursors • Vancomycin is Ototoxic and Nephtrotoxic. ________________________________________________________ B. • Penicillin inhibits Transpeptidation by binding to Penicillin- Binding Proteins (PBPs) and preventing their Transpeptidase Activity • Vancomycin Inhibits Transpeptidation by binding to D-Alanine- D-Alanine of Pentapeptide Side Chains of Peptidoglycan Precursors • Vancomycin is Ototoxic, Nephrotoxic and Hepatotoxic, is inhibited by Calcium and induces Vaginal Yeast Infections. ________________________________________________________ C. • Penicillin inhibits Transpeptidation by binding to Penicillin- Binding Proteins (PBPs) and preventing their Transpeptidase Activity • Vancomycin Inhibits Transpeptidation by binding to D-Alanine- D-Alanine of Pentapeptide Side Chains of Peptidoglycan Precursors • Penicillin is Ototoxic, Nephrotoxic and Hepatotoxic, is inhibited by Calcium and induces Vaginal Yeast Infections.. ________________________________________________________ D. • Penicillin inhibits Transpeptidation by binding to D-Alanine- D-Alanine of Pentapeptide Side Chains of Peptidoglycan Precursors • Vancomycin inhibits Transpeptidation by binding to Penicillin- Binding Proteins (PBPs) and preventing their Transpeptidase Activity • Approximately 01% to 05% of Adults are allergic to Penicillin.
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MIC 101 Exam 1 Page 29 47. Aminoglycosides contain a Cyclohexane Ring and Amino Sugars. All are administered by Injection. They are Ototoxic and Nephrotoxic. What is the Mode of Action of an Aminoglycoside such as Streptomycin?
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