BIO314 Full Practice Exam 2

Which of the following statement is correct a pten is

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7) Which of the following statement is CORRECT? a) PTEN is dispensable during embryonic development b) PTEN homozygous mice are more tumor-prone than PTEN heterozygous mice c) PTEN has phosphorylase activity against Ras signaling and suppresses tumorogenesis d) Rather than loss of one copy of PTEN, complete loss of PTEN is more frequently observed in human tumors. e) None of above 8) You successfully generated a conditional knockout mouse for gene A by using Cre/loxP system. Which of the following statement is TRUE?
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9) You overexpress K-ras G12D in mouse embryonic fibroblasts (MEFs). Which of the following results you may NOT observe? 10) Tumor-suppressor genes are different from oncogenes in which of the following ways? 11) Which of the following statements regarding the Knudson hypothesis and retinoblastoma are true? a) According to the Knudson hypothesis, familial retinoblastoma is caused by the inactivation of a good copy of the Rb gene and most people with this cancer develop multiple tumors in both eyes. b) According to the Knudson hypothesis, sporadic retinoblastoma is caused by the inactivation of the Rb gene twice, in different cell lines, and most people with this cancer develop one tumor in one eye. c) According to the Knudson hypothesis, in a normal healthy individual with no inherited mutant Rb gene, a novel mutation in a cell will induce a tumor. d) According to the Knudson hypothesis, two “hits” on an oncogene will lead to excessive cell proliferation. 12) Which of the following cannot induce a tumor?
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