12 2 what is the uncorrected frequency estimate for

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12 2. What is the uncorrected frequency estimate for this sequence (P Uc )? 9.386e-4 3. What is the corrected frequency estimate for this sequence (P N+1 )? 1.017e-3 4. What geographic affiliation is this sequence most common in? (use the drop-down list under “geographic affiliation” to choose the different major population options – Africa, America, Asia, and Europe – and for each one check the uncorrected frequency estimates) Asia 5. Is your answer to question #4 consistent with the Chinese-American ancestry of the missing boy (why or why not)? Yes, because 11 of the matches were found in Asia 6. The mother's mtDNA has also been sequenced, and matches that of the skeleton. There are currently approximately 5.8 million people living in the Greater Philadelphia metropolitan area. What can you conclude from this (think about your answer to question 3) regarding the likely number of individuals in Philadelphia who would match this child? 1.017e-3*5.8 million= 2
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Now we will try to determine which major matriline ('haplogroup') this sequence belongs to. Go to the mtDNA Manager website (maintained by Yonsei University, in Seoul, Korea), at . A. Note that the 'African' metapopulation is the default target in the 'Target Group', and that the default database is the “FBI-African” database. To change metapopulations, use the dropdown menu. To change databases within each metapopulation, click on the database of choice in the ‘target group’ list (e.g., for the ‘African’ metapopulation, your choices are “FBI-African”, “Kenyan”, and “US-African”). B. In the ‘Sequence’ section, type “16185T 16223T 16260T 16298C” C. Check only the 'HV1' box in the 'Region' section D. Click the ‘Match’ button E. Hit the ‘Worldwide Frequency’ F. This should open a new window that lists the frequency of exact matches to your sequence in all of the various databases available on the site (it might take a while for the data to appear).
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  • Summer '11
  • Tilley
  • DNA, Mitochondrial DNA, Cambridge Reference Sequence, Forensic mtDNA Activity, mtdna population database, mtDNA Manager

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