acid ibuprofen meloxicam ketorolac diclofenac non selective cox 1 and 2 Second

Acid ibuprofen meloxicam ketorolac diclofenac non

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acid, ibuprofen, meloxicam, ketorolac, diclofenac) – non-selective (cox-1 and 2) “Second-generation” (celecoxib) – selective for cox-2 Analgesic, antipyretic, anti-inflammatory effects (and anti- platelet effects with aspirin) NSAIDS – MOA & Clinical Use
NSAIDs and Cox-1 and 2 Source: Adams, M. P., Urban, C. Q., & Sutter, R. E. (2019). Pharmacology: Connections to nursing practice (4 th ed., pg 726). New York, NY: Pearson
Selected Uses NSAID Arthritis Mild to Moderate Pain Fever Dysmenorrhea Other aspirin (and related) X X X X Prevent/treat MI/stroke, colorectal cancer ibuprofen X X X X Acute migraine naproxen X X X X Ankylosing spondylitis meloxicam X diclofenac X X X Ankylosing spondylitis, topical for actinic keratosis, ocular pain & inflammation ketorolac X Topical for allergic conjunctivitis, ocular pain & inflammation celecoxib X X X Ankylosing spondylitis acetaminophen (analgesia) X X (analgesia)
GI upset Tinnitus, ototoxicity Increased BP, HTN (increased risk of stroke and MI) Bleeding Allergic and idiosyncratic reactions Renal toxicity Metabolic acidosis Reye’s syndrome (aspirin) Side/Adverse Effects

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