respiratory tract infections including acute sinusitis, acute exacerbations of chronic bronchitis, and pneumonia, skin/skin structure infections , bone and joint infections , infectious diarrhea , complicated intraabdominal infections (with metronidazole), typhoid fever. Post-exposure prophylaxis of inhalational anthrax. Cutaneous anthrax. Tx and prophylaxis of plague.IVFebrile neutropenia. Unlabeled Use: Acute pulmonaryexacerbations in cystic fibrosisInhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme. Therapeutic Effects: Death of susceptible bacteria. Spectrum: Active against gram + pathogensH/o myasthenia gravis, use with tizanidine; OB: Do not use unless potential benefit outweighs potential fetal risk; Pedi: Use only if no alternatives in children 1– 17 yrs due to possible arthropathyElevated ICP, diarrhea, nausea, hepatotoxicity, anaphylaxis, c diff , may cause↑ serum AST, ALT, LDH, bilirubin, and alkaline phosphatase. May also cause ↑ or ↓glucose. Cystalluria, dizziness, drowsiness, prevent phototoxicity reactionsAssess for infection. Observe for signs & sx's of anaphylaxis. Monitor bowel function. PO: Administer w/o regard to food & w/ a full glass of water, at the same time QD. Products or foods containing calcium, magnesium, aluminum, iron, or zinc should not be ingested for 6 hr before and 2 hr after administration. If gastric irritation occurs, may be administered w/ meals. Encourage pt to maintain a fluid intake of at least 1500– 2000 mL/day. Caution pt to use sunscreen & protective clothing to during & for 5 days after therapy. Obtain specimens for c+s before initiating therapy.