Rapidly absorbed from the GI tract metabolized in the liver and excreted in the

Rapidly absorbed from the gi tract metabolized in the

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Rapidly absorbed from the GI tract, metabolized in the liver and excreted in the urine Contraindications- Known allergy, pregnancy, lactation and known renal and liver dysfunction Adverse Effects- Most significant are headache, dizziness, nausea, diarrhea, and elevated liver enzymes Drug- to–Drug Interactions -increased risk of renal toxicity if these drugs are taken with other nephrotoxic drugs
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Prototype of Hepatitis B Antiviral Agents Prototype of Hepatitis B Antiviral Agents
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Anti-hepatitis C Agents Anti-hepatitis C Agents See Protease Inhibitors o Can be used in combination with ribavirin or ribavirin and peginterferon to treat chronic hepatitis C Technivie , and Paritaprevir
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Locally Active Antiviral Agents Locally Active Antiviral Agents Indications – Act on viruses by interfering with normal viral replication and metabolic processes Pharmacokinetics – Not absorbed systemically Contraindications – Allergy to the drug Adverse Reactions – Local burning, stinging, and discomfort
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Question #4 Question #4 Which antiviral drugs are not absorbed systemically? A. Anti-hepatitis B agents B. Locally Active Antiviral Agents C. Nucleoside Agents D. Fusion Inhibitors
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Answer to Question #4 Answer to Question #4 B. Locally Active Antiviral Agents Rationale: Locally active antiviral drugs are not absorbed systemically, but caution must be used in patients with known allergic reactions to any topical drugs.
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  • Summer '19
  • Dr. Hanley
  • Wolters Kluwer Health,  Hepatitis B,  Viruses

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