Rapidly absorbed from the GI tract metabolized in the liver and excreted in the

Rapidly absorbed from the GI tract, metabolized in the liver and excreted in the urine  Contraindications- Known allergy, pregnancy, lactation and known renal and liver dysfunction  Adverse Effects- Most significant are headache, dizziness, nausea, diarrhea, and elevated liver enzymes  Drug- to–Drug Interactions -increased risk of renal toxicity if these drugs are taken with other nephrotoxic drugs

Copyright © 2017 Wolters Kluwer • All Rights Reserved Anti-hepatitis C Agents Anti-hepatitis C Agents  See Protease Inhibitors o Can be used in combination with ribavirin or ribavirin and peginterferon to treat chronic hepatitis C  Technivie , and Paritaprevir

Copyright © 2017 Wolters Kluwer • All Rights Reserved Locally Active Antiviral Agents Locally Active Antiviral Agents  Indications – Act on viruses by interfering with normal viral replication and metabolic processes  Pharmacokinetics – Not absorbed systemically  Contraindications – Allergy to the drug  Adverse Reactions – Local burning, stinging, and discomfort

Copyright © 2017 Wolters Kluwer • All Rights Reserved Question #4 Question #4 Which antiviral drugs are not absorbed systemically? A. Anti-hepatitis B agents B. Locally Active Antiviral Agents C. Nucleoside Agents D. Fusion Inhibitors

Copyright © 2017 Wolters Kluwer • All Rights Reserved Answer to Question #4 Answer to Question #4 B. Locally Active Antiviral Agents Rationale: Locally active antiviral drugs are not absorbed systemically, but caution must be used in patients with known allergic reactions to any topical drugs.