EPA and DHA are long-chain (20 carbons or more) polyunsaturated fatty acids The fatty acids enter every cell membrane in the human body, serving as a cell lubricant, while improving flexibility and communication between cells, and aiding cell metabolism and gene expression.
Pharmacokinetics of Omega-3 Fish Oil Absorption rate of 95% DHA have a high binding capacity with human plasma proteins at 76-82% Elimination of DHA via urine at 52% Half life of EPA is 37 hours and DHA is 46 hours Metabolism: 3 pathways 1. Incorporated into lipoproteins and stored 2. Act as precursors for eicosanoids 3. The majority of fatty acids oxidized for energy
Side Effects Bleeding Halitosis Hemorrhagic stroke Heartburn Nausea Weight Gain Mild Skin Rash Back pain GI upset
Contraindications/ Interactions Patients on Anticoagulant and anti-platelet drugs : Fish oil can increase the risk of bleeding. Blood Pressure Medication : Fish oil may increase the effects of the blood pressure medication Shellfish or Fish allergy: May cause an allergic reaction History of Bipolar or Depression: May increase symptoms Diabetics: May have difficulty controlling blood glucose
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- Fall '16
- Omega-3 fatty acid, fish oil, Eicosapentaenoic acid, fish oils, DHA, Prevent Cancer