Induces attaching and effacing ae histopathology ae

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• Induces “attaching and effacing” (A/E) histopathology (AE lesions) Bacteria intimately attach to intestinal epithelial cells • A/E lesions -- cause striking actin cytoskeletal changes leading to the formation of actin pedestal Actin EPEC Tir
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Listeria -- Movie
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Natural drugs/toxins can alter actin filament polymerization Natural toxins produced by plants, fungi, or sponges are know to disrupt or stabilize actin dynamics Latrunculin – sea sponge Binds actin monomers and prevents their assembly into filaments (sequestration) Cytochalasin – mold Caps the barbed ends; causes disassembly in cells Phalloidin – inedible mushroom Binds to and stabilizes actin filaments – causes net increase in actin polymerization
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Molecular motors: The motor proteins convert chemical energy (stored in ATP) into mechanical energy, which is used to generate force to move cellular cargo attached to the motor. Types of cargo transported include: ribonuclear protein particles vesicles mitochondria lysosomes chromosomes other cytoskeletal filaments Myosin – The molecular motor of actin filaments
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Structure of conventional myosin – Myosin II
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Figure 16-56 Molecular Biology of the Cell (© Garland Science 2008) Myosin head is sufficient for motor activity
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