4 . Reduced bioavailability time 25. An agonist activates a receptor & stimulates a response. When given frequently over time, the body may: 1 . Upregulate the total number of receptors 2 . Block the receptor with a partial agonist 3 . Alter the drug’s metabolism 4 . Downregulate the numbers of that specific receptor 26. Drug antagonism is best defined as an effect of a drug that: 1 . Leads to major physiological & psychological dependence 2 . Is modified by the concurrent administration of another drug 3 . Cannot be metabolized before another dose is administered 4 . Leads to a decreased physiological response when combined with another drug 27. Instructions to a client regarding self-administration of oral enteric-coated tablets should include which of the following statements? 1 . “Avoid any other oral medicines while taking this drug.” 2 . “If swallowing this tablet is difficult, dissolve it in 3 ounces of orange juice.” 3 . “The tablet may be crushed if you have any difficulty taking it.” 4 . “To achieve best effect, take the tablet with at least 8 ounces of fluid.” 28. The major reason for not crushing a sustained-release capsule is that, if crushed, the coated beads of the drugs could possibly result in: 1 . Disintegration 2 . Toxicity 3 . Malabsorption 4 . Deterioration 29. Which of the following substances is the most likely to be absorbed in the intestines rather than in the stomach? 1 . Sodium bicarbonate 2 . Ascorbic acid 3 . Salicylic acid 4 . Glucose 30. Which of the following variables is a factor in drug absorption? 1 . The smaller the surface area for absorption, the more rapidly the drug is absorbed. 2 . A rich blood supply to the area of absorption leads to better absorption. 3 . The less soluble the drug, the more easily it is absorbed. 4 . Ionized drugs are easily absorbed across the cell membrane. 31. An advantage of prescribing a sublingual medication is that the medication is: 1 . Absorbed rapidly 2 . Excreted rapidly ADV Pharm | TextBook | StudyGuide 5
3 . Metabolized minimally 4 . Distributed equally 32. Drugs that use CYP 3A4 isoenzymes for metabolism may: 1. Induce the metabolism of another drug 2. Inhibit the metabolism of another drug 3. Both 1 & 2 4. Neither 1 nor 2 33. Therapeutic drug levels are drawn when a drug reaches steady state. Drugs reach steady state: 1 . After the second dose 2 . After four to five half-lives 3 . When the patient feels the full effect of the drug 4 . One hour after IV administration 34. Upregulation or hypersensitization may lead to: 1 . Increased response to a drug 2 . Decreased response to a drug 3 . An exaggerated response if the drug is withdrawn 4 . Refractoriness or complete lack of response Chapter 3. Rational Drug Selection 1. An NP would prescribe the liquid form of ibuprofen for a 6-year-old child because: 1 . Drugs given in liquid form are less irritating to the stomach.
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